Consortial Projects

MalariaGEN's research programme is organized into four different Consortial Projects, each of which brings together data and expertise from multiple investigators to achieve a specific scientific objective.

Consortial Project 1: Genome-wide association studies of severe malaria

We are performing genome-wide association (GWA) studies in large numbers of subjects, to identify genetic variants that are associated with resistance or susceptibility to severe malaria. This Consortial Project brings together work that is going on at study sites in 11 malaria-endemic countries. More >>

Consortial Project 2: Genetic determinants of immune responses to malaria

We aim to understand the functional effects of genetic variation on the immune response to malaria, focusing on how polymorphisms in known immune response genes influence antibody production to malarial antigens. This project is based on studies that are going on in seven malaria-endemic countries. More>>

Consortial Project 3: Genome diversity in malaria-endemic regions

We are carrying out DNA sequencing studies to discover new variants in the genomes of different populations that are exposed to malaria, focusing particularly on regions of the genome that appear to affect resistance to malaria. Study sites in 11 malaria-endemic countries are contributing to this Consortial Project. More>>

Consortial Project 4: Genetic linkage studies of resistance to malaria

This project aims to identify the specific genes that are responsible for resistance to malaria, building on the results of previous family-based genetic linkage studies of malaria. This Consortial Project is based on work that is going on at study sites in three malaria-endemic countries. More>>