News Archive

Date:
12 Nov 2014
The Plasmodium Diversity Network Africa (PDNA) has published an analysis of genetic variation in 1,212 P. falciparum samples collected from across 12 African countries. The findings, published in the Journal of Infectious Diseases, provide important baseline information about the prevalence of mutations in the K13 propeller domain in sub-Saharan Africa. The K13 propeller domain was identified in... More »
Date:
28 Sep 2014
In a paper just published in Nature Genetics, the MalariaGEN Consortium reports a major study that set out to replicate the many findings of genetic associations with severe malaria that have been reported in the literature. "In malaria it’s often not possible to replicate findings, because of heterogeneity in host and parasite populations," says Professor Dominic Kwiatkowski of the University of... More »
Date:
12 Sep 2014
Scientists are poised to capture data that will help support efforts to track and respond to the drug-resistant malaria parasites in Africa. The African Plasmodium Diversity Network (PDNA) has been established across eleven countries in sub-Saharan Africa and will help to ensure that scientists are able to work together and perform effective and timely surveillance for the genetic markers of... More »
Date:
31 Jul 2014
Drug-resistant malaria parasites have spread to critical border regions of South-east Asia, seriously threatening global malaria control and elimination programmes, according to a study published in the 'New England Journal of Medicine'. The study confirms that resistance to the world’s most effective antimalarial drug, artemisinin, is now widespread in South-east Asia. This is not the first or... More »
Date:
22 Jul 2014
The seventh Genomic Epidemiology of Malaria conference, more affectionately known as GEM, was hosted by the Wellcome Trust Scientific Conferences Programme on the Genome Campus in Hinxton, from June 8th-11th. This annual gathering provides a common forum for malaria scientists and clinicians working at the interface of genome science and technology, epidemiology, and statistical and population... More »
Date:
25 Jun 2014
Genome sequences of Anopheles gambiae sister species help to investigate insecticide resistance Researchers have exploited a natural experiment created by our use of insecticides to show that large regions of DNA can move between the two types of mosquito that are most important in spread of malaria. The work is important for infection control because it suggests that these mosquitoes can remain... More »
Date:
28 Feb 2014
For the first time, researchers have identified a single protein, PfAP2-G, that acts as the master switch triggering the development of sexual forms of the parasite. Malaria parasites can only reproduce sexually when they are in the gut of the mosquito, after it has ingested the precursor parasite cells present in an infected person's blood— a vulnerable stage of the parasite's complicated life... More »
Date:
10 Jan 2014
Dr Olivo Miotto has written a blog about key discoveries in the ongoing attempts to understand the genetic basis of artemsinin resistance, including the identification of artemisinin resistant P. falciparum founder populations in Cambodia and the artemisinin resistance marker in the kelch propeller domain. Published on the Sanger Institute website, the blog also considers a near-future where... More »
Date:
18 Dec 2013
Findings published today in Nature identify mutations in the PF3D7_1343700 kelch propeller domain or ‘K-13 propeller’ that are associated with experimentally-induced resistance to the frontline malaria drug, artemisinin, and with naturally-occuring artemisinin resistance in Cambodia. Importantly, these mutations could serve as a molecular marker for large-scale surveillance efforts to contain... More »
Date:
29 Nov 2013
This week PLOS ONE published the paper “Association of Cytokine and Toll-Like Receptor Gene Polymorphisms with Severe Malaria in Three Regions of Cameroon” by Tobias Apinjoh et al. The study investigates the effect of single nucleotide polymorphisms (SNPs) on malaria pathology from two major ethnic groups in three regions of Cameroon characterised by their intense perennial transmission of P.... More »

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