News Archive

Date:
31 Jul 2014
Drug-resistant malaria parasites have spread to critical border regions of South-east Asia, seriously threatening global malaria control and elimination programmes, according to a study published in the 'New England Journal of Medicine'. The study confirms that resistance to the world’s most effective antimalarial drug, artemisinin, is now widespread in South-east Asia. This is not the first or... More »
Date:
22 Jul 2014
The seventh Genomic Epidemiology of Malaria conference, more affectionately known as GEM, was hosted by the Wellcome Trust Scientific Conferences Programme on the Genome Campus in Hinxton, from June 8th-11th. This annual gathering provides a common forum for malaria scientists and clinicians working at the interface of genome science and technology, epidemiology, and statistical and population... More »
Date:
25 Jun 2014
Genome sequences of Anopheles gambiae sister species help to investigate insecticide resistance Researchers have exploited a natural experiment created by our use of insecticides to show that large regions of DNA can move between the two types of mosquito that are most important in spread of malaria. The work is important for infection control because it suggests that these mosquitoes can remain... More »
Date:
28 Feb 2014
For the first time, researchers have identified a single protein, PfAP2-G, that acts as the master switch triggering the development of sexual forms of the parasite. Malaria parasites can only reproduce sexually when they are in the gut of the mosquito, after it has ingested the precursor parasite cells present in an infected person's blood— a vulnerable stage of the parasite's complicated life... More »
Date:
10 Jan 2014
Dr Olivo Miotto has written a blog about key discoveries in the ongoing attempts to understand the genetic basis of artemsinin resistance, including the identification of artemisinin resistant P. falciparum founder populations in Cambodia and the artemisinin resistance marker in the kelch propeller domain. Published on the Sanger Institute website, the blog also considers a near-future where... More »
Date:
18 Dec 2013
Findings published today in Nature identify mutations in the PF3D7_1343700 kelch propeller domain or ‘K-13 propeller’ that are associated with experimentally-induced resistance to the frontline malaria drug, artemisinin, and with naturally-occuring artemisinin resistance in Cambodia. Importantly, these mutations could serve as a molecular marker for large-scale surveillance efforts to contain... More »
Date:
29 Nov 2013
This week PLOS ONE published the paper “Association of Cytokine and Toll-Like Receptor Gene Polymorphisms with Severe Malaria in Three Regions of Cameroon” by Tobias Apinjoh et al. The study investigates the effect of single nucleotide polymorphisms (SNPs) on malaria pathology from two major ethnic groups in three regions of Cameroon characterised by their intense perennial transmission of P.... More »
Date:
1 Nov 2013
The Wellcome Trust Sanger Institute is accepting applications for the 2014 Sanger Institute Prize. The winner will receive a three month internship with a research group at the Wellcome Trust Sanger Institute during the Summer of 2014. The competition is open to undergraduate students from low and middle income countries. Entrants should have a strong and demonstrable interest in genomics, and a... More »
Date:
15 Oct 2013
Earlier this month, researchers at The Malaria Research and Training Centre, University of Bamako, Mali working in collaboration with the MalariaGEN Consortium, published a paper titled “Human Candidate Polymorphisms in Sympatric Ethnic Groups Differing in Malaria Susceptibility in Mali.” The research focuses on how susceptibility to malaria differs between the Fulani and Dogon ethnic groups in... More »
Date:
8 Oct 2013
Explore a beta release of a new web application designed to share the findings of the MalariaGEN P. falciparum Community Project, an international collaboration that is working with partners in over 20 malaria-endemic countries to understand genetic variation in malaria parasites. The Project's primary goal is to establish a global repository of population genomic data for P. falciparum. To... More »

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