Signatures of Plasmodium falciparum population structure
The MalariaGEN team worked with many groups around the world to establish the Plasmodium falciparum population genomics community project, including developing field sample handling methods, sequencing protocols, and data analysis pipelines. These sample sets also underpinned MalariaGEN’s initial global map of Plasmodium genome variation, and provided opportunities to explore unique features of the population genetics of parasite populations of the local region from where they were collected.
In Mali, Abdoulaye Djimde and colleagues worked with Sarah Auburn in the MalariaGEN team to collect parasite samples from two sites: Kolle and Faladje, rural villages approximately 60 and 80km away from Bamako, the capital of Mali. Samples were used to develop field-friendly leukocyte depletion methods, GoldenGate genotyping assay development, and to contribute to our global P. falciparum genome variation data analysis. Djimde and team are keen to investigate signatures of population structure and other unique features of genome variation between the 2 locations from which samples were collected.
Malaria Research and Training Centre, Faculty of Science, Techniques and Technologies, University of Bamako, Mali
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