Pan-African Malaria Genetic Epidemiology Network (PAMGEN)
Started 2017
This project aims to create a robust network of African scientists – within and outside Africa– in collaboration with leading researchers around the world, who use the latest genetics and genomics science to contribute towards malaria elimination efforts in Africa. By combining data from across the continent and from across human, parasite, and vector samples, PAMGEN will better understand the deadly evolutionary arms race of malaria.
Objectives & Coordination
The three goals of PAMGEN are to:
- Create sustainable, innovative strategies and methods to collect, manage, share and analyse standardised data on human and parasite genetic variation, gene-disease associtions, and gene-environment interactions
- Nurture African leadership by identifying and training the next generation of African researchers through advanced degree programmes in genetics and genomics; large-scal datga analysis; and bioethics.
- Use human, parasite, and vector population and functional genomics research to drive the development of new tools to support malaria elimination programmes across Africa.
Sampling locations
Partner studies
The project is divided into four separate studies, according to P. falciparum parasite data, P. vivax parasite data, vector data and human data.
PAMGEN sites
People
The PAMGEN project is ambitious and wide-ranging. Its principal investigators span the African continent and have deep experience analysing human, parasite, and vector genomes.
Principal Investigators
The Principal Investigators for PAMGEN represent leading institutions in seven countries across Africa.
Prof Abdoulaye Djimdé
Associate Professor of Parasitology and Mycology; Chief of the Molecular Epidemiology and Drug Resistance Unit
Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Mali
Projects
- Consortial Project 2
- P. falciparum Community Project
- Pan-African Malaria Genetic Epidemiology Network (PAMGEN)
- Pf3k
Partner studies
- 1001 Developing the Community Project with partners in Mali
- 1097 Detection of artemisinin-resistant Plasmodium falciparum parasites in Southern Mali
- 1127 Genetic analysis of Plasmodium falciparum before and after artemether-lumefantrine treatment in Mali
- 1164 Plasmodium falciparum clearance times in Malian villages following artesunate monotherapy
- 1199 Developing SpotMalaria with partners in Mali
- Studies of malaria immunity in Manteourou, Mali
- Studies of malaria immunity in Pongonon, Mali
Prof Alfred Amambua-Ngwa
Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, The Gambia
Wellcome Sanger Institute, UK
Projects
- Genomic Surveillance Hubs in West Africa (NIHR Global Health Research Group)
- P. falciparum Community Project
- Pan-African Malaria Genetic Epidemiology Network (PAMGEN)
- Pf3k
Partner studies
- 1006 Genome-wide analysis of genetic variation in The Gambia
- 1026 Effects of transmission intensity on population structure and signatures of selection in Guinea
- 1103 Population genetics of cross-border Plasmodium falciparum parasites in West Africa
- 1136 Plasmodium falciparum anti-malarial drug resistance in The Gambia: Identification of potential genetic markers by retrospective whole genome approaches
- 1137 Malaria transmission dynamics in The Gambia: Defining the spatial and temporal spread of malaria at micro-level (village)
- 1162 Genomic variation and antimalarial resistance evolution in The Gambia
- 1182 Understanding the determinants of malaria heterogeneity and the spatial and temporal spread of malaria in The Gambia
- 1268 Pan-African Malaria Genetic Epidemiology Network (PAMGEN) Plasmodium falciparum samples
- 1306 Genetic diversity of Malaria parasites in Nigeria
Dr Deus Ishengoma
Researcher
National Institute for Medical Research (NIMR), United Republic of Tanzania
Researcher
East African Consortium for Clinical Research (EACCR), United Republic of Tanzania
MalariaGEN Affiliations
Projects
- Consortial Project 2
- P. falciparum Community Project
- Pan-African Malaria Genetic Epidemiology Network (PAMGEN)
Partner studies
- 1095 Genome variation and its affect on ACT treatment outcome in Tanzania
- 1167 Surveillance of parasite populations and patterns of drug resistance, and associated parasite clearance or treatment failure in Tanzania
- 1268 Pan-African Malaria Genetic Epidemiology Network (PAMGEN) Plasmodium falciparum samples
- Studies of malaria immunity in Tanga, Tanzania
Dr Lemu Golassa
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Ethiopia
Dr Lucas Amenga-Etego
West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Ghana
Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana
MalariaGEN Affiliations
Projects
- Consortial Project 1
- Consortial Project 3
- Genomic Surveillance Hubs in West Africa (NIHR Global Health Research Group)
- P. falciparum Community Project
- Pan-African Malaria Genetic Epidemiology Network (PAMGEN)
- Pf3k
Partner studies
- 1017 Population genetics of natural populations in Northern Ghana
- 1094 Population genetics of Plasmodium falciparum parasites in Northern Ghana
- 1151 Testing the effectiveness of selective whole genome amplification on samples collected in Northern Ghana
- 1168 Genomic surveillance of Plasmodium falciparum in the Kassena-Nankana Districts, Ghana
- 1183 Alternative mechanisms for erythrocyte invasion by Plasmodium falciparum
- 1268 Pan-African Malaria Genetic Epidemiology Network (PAMGEN) Plasmodium falciparum samples
- 1294 Investigation of Host and Parasite Genetic Factors Mediating asymptomatic Plasmodium falciparum infections
- Human genetic determinants of severe malaria in the Kassena-Nankana District of Northern Ghana
Professor Milijaona Randrianarivelojosia
Head of Malaria Research Unit
Institut Pasteur de Madagascar
Part-time lecturer
Universités d\'Antananarivo et de Mahajanga, Madagascar
Dr Tobias Apinjoh
Biochemist and Researcher
University of Buea, Cameroon
MalariaGEN Affiliations
Projects
- Consortial Project 1
- Consortial Project 3
- P. falciparum Community Project
- Pan-African Malaria Genetic Epidemiology Network (PAMGEN)
Partner studies
- 1093 Population genetics of Plasmodium falciparum parasites in South-Western Cameroon
- 1165 Prevalence of gene polymorphisms in symptomatic and asymptomatic Plasmodium falciparum infected individuals from the Southwest region of Cameroon
- 1268 Pan-African Malaria Genetic Epidemiology Network (PAMGEN) Plasmodium falciparum samples
- Human genetic determinants of severe malaria in three regions of Cameroon
