Data Available

The following data have been deposited at the European Genotyping Archive:

Gambian Case Control Study of Severe Malaria

• a pilot study as part of Consortial Project 1
• 1059 samples from cases of severe malaria
• 1496 cord blood control samples
• genotyped on Affymetrix 500k gene chip

For each of these samples, one set of genotypes - called by CHIAMO - is available, as discussed and used in the analysis by the Wellcome Trust Case Control Consortium (WTCCC).

This dataset can be accessed for the following purposes:

• research into malaria and other specific diseases
• relevant methodological research and teaching - such as the development of biostatistical methods and applications for analysing and interpreting genome-wide data

The use of data for research purposes that are not directly relevant to health, such as anthropological research to understand the history of human populations, will be referred by the Independent Data Access Committee to the relevant research ethics committee in The Gambia on a case-by-case basis. In such cases the application should incorporate detailed information on the study hypothesis and the likely outcomes and conclusions, including any potential impact these may have on health.

Trio Datasets from Gambia, Ghana and Malawi

Data sets currently available from Consortial Project 1

• 666 Gambian mother-father-child trios (including 8 pairs of siblings) 

Data sets currently under consideration by ethics committees:

• 608 Ghanaian mother-father-child trios 
• 122 Malawian mother-father-child trios

All samples were genotyped on the Illumina 650Y array. All children have been diagnosed with malaria in a hospital. This data release contains complete trios that have passed quality control.