Publications

Latest publications

24 Mar 2016

Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies

Tripura R, Peto TJ, Chalk J, Lee SJ, Sirithiranont P, Nguon C, Dhorda M, von Seidlein L, Maude RJ, Day NP, Imwong M, White NJ, Dondorp AM.
Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies 2016 15 181 DOI: 10.1186/s12936-016-1224-7
8 Mar 2016

The ethics of sustainable genomic research in Africa

Parker M, Kwiatkowski DP
Genome Biology 2016 17 44 DOI: 10.1186/s13059-016-0914-3
4 Mar 2016

Genomic epidemiology of artemisinin resistant malaria

MalariaGEN P. falciparum Community Project
eLife 2016 5 e08714 DOI: 10.7554/eLife.08714
30 Sep 2015

A novel locus of resistance to severe malaria in a region of ancient balancing selection

Malaria Genomic Epidemiology Network
Nature 2015 526(7572) 253-257 DOI: 10.1038/nature15390
28 Aug 2015

Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Shelton JM, Corran P, Risley P, Silva N, Hubbart C, Jeffreys A, Rowlands K, Craik R, Cornelius V, Hensmann M, Molloy S, Sepulveda N, Clark TG, Band G, Clarke GM, Spencer CC, Kerasidou A, Campino S, Auburn S, Tall A, Ly AB, Mercereau-Puijalon O, Sakuntabhai A, Djimdé A, Maiga B, Touré O, Doumbo OK, Dolo A, Troye-Blomberg M, Mangano VD, Verra F, Modiano D, Bougouma E, Sirima SB, Ibrahim M, Hussain A, Eid N, Elzein A, Mohammed H, Elhassan A, Elhassan I, Williams TN, Ndila C, Macharia A, Marsh K, Manjurano A, Reyburn H, Lemnge M, Ishengoma D, Carter R, Karunaweera N, Fernando D, Dewasurendra R, Drakeley CJ, Riley EM, Kwiatkowski DP, Rockett KA; MalariaGEN Consortium
Malaria Journal 2015 14 333 DOI: 10.1186/s12936-015-0833-x
16 Jul 2015

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity

Duffy CW, Assefa SA, Abugri J, Amoako N, Owusu-Agyei S, Anyorigiya T, MacInnis B, Kwiatkowski DP, Conway DJ, Awandare GA
BMC Genomics 2015 16 527 DOI: 10.1186/s12864-015-1746-3
16 Jun 2015

Understandings of genomic research in developing countries: a qualitative study of the views of MalariaGEN participants in Mali

Traore K, Bull S, Niare A, Konate S, Thera MA, Kwiatkowski D, Parker M, Doumbo OK
BMC Medical Ethics 2015 16 42 DOI: 10.1186/s12910-015-0035-7
15 Apr 2015

K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa

Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D, Johnson K, Mumba D, Kekre M, Yavo W, Mead D, Bouyou-Akotet M, Apinjoh T, Golassa L, Randrianarivelojosia M, Andagalu B, Maiga-Ascofare O, Amambua-Ngwa A, Tindana P, Ghansah A, MacInnis B, Kwiatkowski D, Djimde AA
Journal of Infectious Diseases 2015 211(8) 1352-5 DOI: 10.1093/infdis/jiu608
24 Mar 2015

USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania

Manjurano A, Sepúlveda N, Nadjm B, Mtove G, Wangai H, Maxwell C, Olomi R, Reyburn H, Drakeley CJ, Riley EM, Clark TG; in Collaboration With MalariaGEN
Journal of Infectious Diseases 2015 212(7) 1129-39 DOI: 10.1093/infdis/jiv192
23 Feb 2015

Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia

Mangano VD, Kabore Y, Bougouma EC, Verra F, Sepulveda N, Bisseye C, Santolamazza F, Avellino P, Tiono AB, Diarra A, Nebie I, Rockett KA, Sirima SB, Modiano D; MalariaGEN Consortium
Journal of Infectious Diseases 2015 212(4) 626-34 DOI: 10.1093/infdis/jiv098
22 Feb 2015

G6PD gene variants and its association with malaria in a Sri Lankan population

Dewasurendra RL, Rockett KA, Fernando SD, Carter R, Kwiatkowski DP, Karunaweera ND; MalariaGEN Consortium
Malaria Journal 2015 14 93 DOI: 10.1186/s12936-015-0603-9
11 Feb 2015

African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania

Manjurano A, Sepulveda N, Nadjm B, Mtove G, Wangai H, Maxwell C, Olomi R, Reyburn H, Riley EM, Drakeley CJ, Clark TG; MalariaGEN Consortium
PloS Genetics 2015 11(2) e1004960 DOI: 10.1371/journal.pgen.1004960
19 Jan 2015

Genetic architecture of artemisinin-resistant Plasmodium falciparum

Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J, Amaratunga C, Lim P, Mead D, Oyola SO, Dhorda M, Imwong M, Woodrow C, Manske M, Stalker J, Drury E, Campino S, Amenga-Etego L, Thanh TN, Tran HT, Ringwald P, Bethell D, Nosten F, Phyo AP, Pukrittayakamee S, Chotivanich K, Chuor CM, Nguon C, Suon S, Sreng S, Newton PN, Mayxay M, Khanthavong M, Hongvanthong B, Htut Y, Han KT, Kyaw MP, Faiz MA, Fanello C, Onyamboko M, Mokuolu OA, Jacob CG, Takala-Harrison S, Plowe CV, Day NP, Dondorp AM, Spencer CC, McVean G, Fairhurst RM, White NJ, Kwiatkowski DP
Nature Genetics 2015 47(3) 226-34 DOI: 10.1038/ng.3189
15 Dec 2014

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates

Ocholla H, Preston MD, Mipando M, Jensen AT, Campino S, MacInnis B, Alcock D, Terlouw A, Zongo I, Oudraogo JB, Djimde AA, Assefa S, Doumbo OK, Borrmann S, Nzila A, Marsh K, Fairhurst RM, Nosten F, Anderson TJ, Kwiatkowski DP, Craig A, Clark TG, Montgomery J
Journal of Infectious Diseases 2014 210(12) 1991-2000 DOI: 10.1093/infdis/jiu349
28 Sep 2014

Reappraisal of known malaria resistance loci in a large multi-centre study

Rockett KA, Clarke GM, Fitzpatrick K, Hubbart C, Jeffreys AE, Rowlands K, Craik R, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu O, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NT, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Green A, Molloy S, Johnson KJ, Kerasidou A, Cornelius V, Hart L, Vanderwal A, SanJoaquin M, Band G, Le SQ, Pirinen M, Sepúlveda N, Spencer CC, Clark TG, Agbenyega T, Achidi E, Doumbo O, Farrar J, Marsh K, Taylor T, Kwiatkowski DP for Malaria Genomic Epidemiology Network
Nature Genetics 2014 46(11) 1197-204 DOI: 10.1038/ng.3107
13 Aug 2014

Knowing who to trust: exploring the role of 'ethical metadata' in mediating risk of harm in collaborative genomics research in Africa

de Vries J, Williams TN, Bojang K, Kwiatkowski DP, Fitzpatrick R, Parker M
BMC Medical Ethics 2014 15 62 DOI: 10.1186/1472-6939-15-62
11 Jul 2014

Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali

Maiga B, Dolo A, Campino S, Sepulveda N, Corran P, Rockett KA, Troye-Blomberg M, Doumbo OK, Clark TG
Malaria Journal 2014 13 270 DOI: 10.1186/1475-2875-13-270
25 Jun 2014

Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation

Clarkson CS, Weetman D, Essandoh J, Yawson AE, Maslen G, Manske M, Field SG, Webster M, Antão T, MacInnis B, Kwiatkowski D, Donnelly MJ
Nature Communications 2014 5 4248 DOI: 10.1038/ncomms5248
16 Jun 2014

Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study

Apinjoh TO, Anchang-Kimbi JK, Njua-Yafi C, Ngwai AN, Mugri RN, Clark TG, Rockett KA, Kwiatkowski DP, Achidi EA; MalariaGEN Consortium
Malaria Journal 2014 13 236 DOI: 10.1186/1475-2875-13-236
13 Jun 2014

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains

Preston MD, Campino S, Assefa SA, Echeverry DF, Ocholla H, Amambua-Ngwa A, Stewart LB, Conway DJ, Borrmann S, Michon P, Zongo I, Ouédraogo JB, Djimde AA, Doumbo OK, Nosten F, Pain A, Bousema T, Drakeley CJ, Fairhurst RM, Sutherland CJ, Roper C, Clark TG.
Nature Communications 2014 5 4052 DOI: 10.1038/ncomms5052
27 Nov 2013

Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon

Apinjoh TO, Anchang-Kimbi JK, Njua-Yafi C, Mugri RN, Ngwai AN, Rockett KA, Mbunwe E, Besingi RN, Clark TG, Kwiatkowski DP, Achidi EA; MalariaGEN Consortium
PLoS One 2013 8(11) e81071 DOI: 10.1371/journal.pone.0081071
2 Oct 2013

Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali

Maiga B, Dolo A, Touré O, Dara V, Tapily A, Campino S, Sepulveda N, Risley P, Silva N, Corran P, Rockett KA, Kwiatkowski D; MalariaGEN Consortium, Clark TG, Troye-Blomberg M, Doumbo OK
PLoS One 2013 8(10) e75675 DOI: 10.1371/journal.pone.0075675
23 May 2013

Imputation-based meta-analysis of severe malaria in three African populations

Band G, Le QS, Jostins L, Pirinen M, Kivinen K, Jallow M, Sisay-Joof F, Bojang K, Pinder M, Sirugo G, Conway DJ, Nyirongo V, Kachala D, Molyneux M, Taylor T, Ndila C, Peshu N, Marsh K, Williams TN, Alcock D, Andrews R, Edkins S, Gray E, Hubbart C, Jeffreys A, Rowlands K, Schuldt K, Clark TG, Small KS, Teo YY, Kwiatkowski DP, Rockett KA, Barrett JC, Spencer CC; Malaria Genomic Epidemiology Network
PloS Genetics 2013 9(5) e1003509 DOI: 10.1371/journal.pgen.1003509
28 Apr 2013

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Duong S, Nguon C, Chuor CM, Saunders D, Se Y, Lon C, Fukuda MM, Amenga-Etego L, Hodgson AV, Asoala V, Imwong M, Takala-Harrison S, Nosten F, Su XZ, Ringwald P, Ariey F, Dolecek C, Hien TT, Boni MF, Thai CQ, Amambua-Ngwa A, Conway DJ, Djimdé AA, Doumbo OK, Zongo I, Ouedraogo JB, Alcock D, Drury E, Auburn S, Koch O, Sanders M, Hubbart C, Maslen G, Ruano-Rubio V, Jyothi D, Miles A, O'Brien J, Gamble C, Oyola SO, Rayner JC, Newbold CI, Berriman M, Spencer CC, McVean G, Day NP, White NJ, Bethell D, Dondorp AM, Plowe CV, Fairhurst RM, Kwiatkowski DP
Nature Genetics 2013 45(6) 648-55 DOI: 10.1038/ng.2624
1 Nov 2012

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites

Amambua-Ngwa A, Tetteh KK, Manske M, Gomez-Escobar N, Stewart LB, Deerhake ME, Cheeseman IH, Newbold CI, Holder AA, Knuepfer E, Janha O, Jallow M, Campino S, Macinnis B, Kwiatkowski DP, Conway DJ
PLoS Genetics 2012 8(11) e1002992 DOI: 10.1371/journal.pgen.1002992
29 Oct 2012

Candidate human genetic polymorphisms and severe malaria in a Tanzanian population

Manjurano A, Clark TG, Nadjm B, Mtove G, Wangai H, Sepulveda N, Campino SG, Maxwell C, Olomi R, Rockett KR, Jeffreys A, MalariaGen Consortium, Riley EM, Reyburn H, Drakeley C
PLoS One 2012 7(10) e47463 DOI: 10.1371/journal.pone.0047463
5 Sep 2012

Candidate polymorphisms and severe malaria in a Malian population

Toure O, Konate S, Sissoko S, Niangaly A, Barry A, Sall AH, Diarra E, Poudiougou B, Sepulveda N, Campino S, Rockett KA, Clark TG, Thera MA, Doumbo O; in collaboration with the MalariaGEN Consortium
PLoS One 2012 7(9) e43987 DOI: 10.1371/journal.pone.0043987
1 Sep 2012

Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese

Dunstan SJ, Rockett KA, Quyen NT, Teo YY, Thai CQ, Hang NT, Jeffreys A, Clark TG, Small KS, Simmons CP, Day N, O'Riordan SE, Kwiatkowski DP, Farrar J, Phu NH, Hien TT; MalariaGEN Consortium
Genes Immunology 2012 13(6) 503-8 DOI: 10.1038/gene.2012.25
20 Aug 2012

Genetic polymorphisms associated with anti-malarial antibody levels in a low and unstable malaria transmission area in southern Sri Lanka

Dewasurendra RL, Suriyaphol P, Fernando SD, Carter R, Rockett K, Corran P, Kwiatkowski D, Karunaweera ND; MalariaGEN Consortium
Malaria Journal 2012 11 281 DOI: doi:10.1186/1475-2875-11-281
19 Jul 2012

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O'Brien J, Djimde A, Doumbo O, Zongo I, Ouedraogo JB, Michon P, Mueller I, Siba P, Nzila A, Borrmann S, Kiara SM, Marsh K, Jiang H, Su XZ, Amaratunga C, Fairhurst R, Socheat D, Nosten F, Imwong M, White NJ, Sanders M, Anastasi E, Alcock D, Drury E, Oyola S, Quail MA, Turner DJ, Ruano-Rubio V, Jyothi D, Amenga-Etego L, Hubbart C, Jeffreys A, Rowlands K, Sutherland C, Roper C, Mangano V, Modiano D, Tan JC, Ferdig MT, Amambua-Ngwa A, Conway DJ, Takala-Harrison S, Plowe CV, Rayner JC, Rockett KA, Clark TG, Newbold CI, Berriman M, MacInnis B, Kwiatkowski DP
Nature 2012 487(7407) 375-9 DOI: 10.1038/nature11174