1015 Genome-wide association study of in vitro drug resistance in Kenya


Locations: Kenya (KE)

Partner study description

As a part of clinical studies being undertaken by the KEMRI-Wellcome Trust Research Programme, samples were collected in the Kilifi district of Kenya. Alexis Nzila and his colleagues adapted these field isolates to laboratory culture and tested their in vitro sensitivity to antimalarial drugs including lumefantrine, chloroquine, piperaquine and dihydroartemisinin (DHA). The phenotypic data are now being used in genome-wide association studies with parasite genotypes generated by Illumina sequencing to identify regions associated to decreased sensitivity to the antimalarial drugs.

Key People

Prof Alexis Nzila
Associate Professor
King Fahid University of Petroleum and Minerals (KFUMP), Saudi Arabia
Prof Steffen Borrmann
Institute for Tropical Medicine, University of Tübingen, Germany