This study aims to correlate protection from malaria with the immune profile of infected individuals. Cross-sectional and longitudinal studies were conducted in all-age cohorts living in Apac, northern Uganda. This area is characterised by intense perennial malaria transmission with Plasmodium falciparum as major malaria species, and Plasmodium malariae and Plasmodium ovale as prevalent other species. Detailed immune-profiling is undertaken by protein microarray, and individuals protected and unprotected from clinical malaria episodes are compared. Site and cohort descriptions are given in http://www.ncbi.nlm.nih.gov/pubmed/23473542 and http://www.ncbi.nlm.nih.gov/pubmed/21540398