This study aims to correlate protection from malaria with the immune profile of infected individuals. Cross-sectional and longitudinal studies were conducted in all-age cohorts living in Apac, northern Uganda. This area is characterised by intense perennial malaria transmission with Plasmodium falciparum as major malaria species, and Plasmodium malariae and Plasmodium ovale as prevalent other species. Detailed immune-profiling is undertaken by protein microarray, and individuals protected and unprotected from clinical malaria episodes are compared. Site and cohort descriptions are given in http://www.ncbi.nlm.nih.gov/pubmed/23473542 and http://www.ncbi.nlm.nih.gov/pubmed/21540398

Publications

• Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda
  Proietti et al
  Parasite Immunology, 2013; 35(5-6) 164-73
  10.1111/pim.12031
• Plasmodium malariae and Plasmodium ovale infections and their association with common red blood cell polymorphisms in a highly endemic area of Uganda
  Subissi et al
  Transactions of The Royal Society of Tropical Medicine and Hygiene, 2019; 113(7) 370-378
  10.1093/trstmh/trz015
• Genomic epidemiology of artemisinin resistant malaria
  MalariaGEN P. falciparum Community Project
  eLife, 2016; 5 e08714
  10.7554/eLife.08714