1146 Characterisation of drug resistance in Plasmodium falciparum populations


Locations: Indonesia (ID)

Partner study description

Ric Price and Rintis Noviyanti are the principal investigators in a genome-wide study aiming to characterise the molecular profile of drug resistance-conferring variants in Indonesian Plasmodium falciparum populations. The study entails genome-wide scans to identify novel resistance variants as well as characterising known variants in P. falciparum field isolates with ex vivo-determined drug sensitivity profiles for a range of antimalarial drugs. Samples are contributed by consenting patients attending local health centres and hospitals in Indonesia. The study is conducted alongside a genome-wide scan to identify and characterise drug-resistance conferring variants in P. vivax field isolates sourced from co-endemic sites in Indonesia and from Thailand. These studies are coordinated by Sarah Auburn and Jutta Marfurt.

Key People

Prof Ric N Price
Professor of Tropical Medicine
Centre for Tropical Medicine and Global Health, University of Oxford, UK
Professor of Global Health
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Mahidol-Oxford Tropical Medicine Research Unit (MORU), Thailand