Targeted Malaria Elimination (TME) studies took place in western Myanmar, Vietnam, Cambodia, and Laos during 2013-17, led by the Mahidol-Oxford Tropical Medicine Research Unit. This project consisted of 2 stages. Firstly, multiple malaria prevalence surveys and collection of treatment records to define the epidemiology of the asymptomatic reservoir, infection risk factors, prevalence of simian malarias, and spatio-temporal mapping. Secondly, a controlled clinical trial of mass drug administration which successfully interrupted falciparum transmission. MORU’s project was funded by the Wellcome Trust and the Bill and Melinda Gates Foundation.