Consortial Project 3 used whole genome sequencing to identify genetic diversity in genes known to be associated with resistance to severe malaria, within and across malaria-endemic populations.
Our primary objective was to characterise genetic diversity in genes known to be associated with malaria.This work has involved:
This project began shortly after MalariaGEN was formed in 2005, and has greatly influenced our approach to collaborative science.
Samples were collected from 2,217 individuals through a number of community-based studies.
Some data used in this project is available through the 1000 Genomes FTP site and the European Nucleotide Archive.
Whole genome sequence data on 374 individuals from six ethic groups from 3 countries.
Low coverage sequencing of the Fula, Jola, Mandinka and Woloff from Gambia Western Division.
Investigators involved in Consortial Project 3 include: