Malaria during pregnancy is an important cause of maternal and fetal morbidity and mortality. In compliance with WHO recommendations, Mozambique introduced intermittent preventive treatment with Sulfadoxine/Pyrimethamine (IPTp-SP) as standard of care for malaria control in pregnant women in 2006. However, the proportion of pregnant women who benefit from this program is still low and there is poor adherence to the adequate IPTp-SP regimen, particularly in rural communities. Careful investigations for better implementation and approaches targeting specifically the rural population are needed. The aim of this project is to contribute to the efforts towards malaria control by assessing the coverage of IPTp-SP and its effect on malaria outcomes, SP-resistance and gametocyte carriage in Chókwé district, Gaza Province, Southern Mozambique.