Malaria candidate SNP survey in Mali

News article
13 September 2012

Last week, Consortial Project 1 partners published a study exploring the influence of sixty-four malaria candidate SNPs, including the sickle-cell polymorphism (HbS), on severe malaria in a case-control study consisting of over 900 individuals from Bamako, Mali. The findings support known protective effects of the blood group O and the HbS AS genotype in relation to life-threatening malaria as well as demonstrating a marginal susceptibility effect for the CD40 ligand (CD40L)+220C allele.


Toure et al. Candidate Polymorphisms and Severe Malaria in a Malian Population.PLoS One. 2012;7(9):e43987. doi: 10.1371/journal.pone.0043987. Epub 2012 Sep 5.