Genomic data resources
MalariaGEN supports malaria elimination efforts in all malaria-endemic regions by building a genomic data resource that provides a lens through which parasite and mosquito populations can be observed, monitored and targeted with effective control interventions.
Genomic epidemiology of malaria
By integrating genomic data with epidemiological data, we aim to tackle key challenges in malaria control, including the development of effective genomic surveillance of drug and insecticide resistance, and identifying and validating new drug and vaccine targets.
Partner studies of parasites and mosquitoes
Since 2017, the Wellcome Sanger Institute has been working towards the capability to sequence 10,000 parasites and 10,000 individual mosquito genomes each year from the samples provided by MalariaGEN partner studies. This genomic data has created high-value, analysis-ready resources, which includes annotated variant calls and phased haplotypes, as well as population-level data such as allele frequencies and maps of the distribution and spread of insecticide or drug resistance mutations. By bringing together genomic data on Plasmodium parasites and Anopheles mosquitoes, MalariaGEN partners have built the world's largest reference data resource for the species that cause and transmit malaria.
The objectives of contributing studies may vary depending on the study species and region, however they all support:
- Evaluating which control interventions are most effective in which setting
- Informing decisions about where and how to allocate resources for malaria control
- Studying the molecular basis, evolution and spread of drug and insecticide resistance
- Identifying opportunities to prolong and maximise the efficacy of malaria control tools
- Investigating the basic epidemiology, ecology and life history of parasites and mosquito populations in different geographical regions.