Untangling mosquito mutation nomenclature


The Ag1000G release of 765 Anopheles gambiae and coluzzii mosquito genomes is enabling investigation of these medically important malaria vector species at a resolution and breadth never possible before.

Perhaps the most striking genetic feature of these mosquitoes is the vast wealth of diversity found across their genomes – nearly one single nucleotide polymorphism (SNP) for every two bases of the reference genome. With this genetic diversity has come the discovery of many previously undetected non-synonymous (protein altering) mutations.

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