At the University of Buea we are performing a family trio study to investigate the genomic basis of resistance against malaria for Consortial Project 3. For this study we needed to identify families where the mother, father and child were all willing to participate. To do this we faced multiple challenges around designing appropriate informed consent processes.
Resistance to malaria
Malaria causes one in ten of all deaths among children in sub-Saharan Africa, with more than 600,000 dying each year from over 200 million reported cases.
Although the number of deaths is staggeringly high, this is a mortality rate of only 0.3%. Early diagnosis and proper treatment are crucial to prevent death, but it is known that some individuals naturally resist malaria severity.