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Malaria candidate SNP survey in Mali

Last week, Consortial Project 1 partners published a study exploring the influence of sixty-four malaria candidate SNPs, including the sickle-cell polymorphism (HbS), on severe malaria in a case-control study consisting of over 900 individuals from Bamako, Mali. The findings support known protective effects of the blood group O and the HbS AS genotype in relation to life-threatening malaria as well as demonstrating a marginal susceptibility effect for the CD40 ligand (CD40L)+220C allele.

News 13 Sep 2012