NEW: Vector genomics fellows... more
Featured publications using MalariaGEN data

15 Jun 2023
Genome-wide association study identifies novel candidate malaria resistance genes in Cameroon
Esoh KK et al
Human Molecular Genetics, 2023; 32(12) 1946-1958.
DOI: 10.1093/hmg/ddad026

20 Jan 2023
Genetic Epidemiology Use Cases for Malaria Control Programmes: A Methodology
Olivo Miotto, Principal Investigator, GenRe-Mekong Project
Genetic Epidemiology Use Cases for Malaria Control Programmes: A Methodology, 2023;

Learn more

28 Nov 2022
Population genomics reveal distinct and diverging populations of An. minimus in Cambodia
St. Laurent et al.
Nature Communications Biology, 2022; 28;5(1) 1308
DOI: 10.1038/s42003-022-04259-y

8 Apr 2022
Plasmodium malariae and Plasmodium ovale infections and their association with common red blood cell polymorphisms in a highly endemic area of Uganda
Subissi et al
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2019; 113(7) 370-378
DOI: 10.1093/trstmh/trz015

9 Dec 2021
The protective effect of sickle cell haemoglobin against severe malaria depends on parasite genotype
Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy Nguyen, Sónia Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto Amato, Eleanor Drury, Giorgio Sirugo, Umberto d’Alessandro, Kalifa A. Bojang, Kevin Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor, David J. Conway, Thomas N. Williams, Kirk A. Rockett & Dominic P. Kwiatkowski
Malaria protection due to sickle haemoglobin depends on parasite genotype, 2021;
DOI: 10.1038/s41586-021-04288-3

Learn more

5 May 2021
Contemporary Ne estimation using temporally spaced data with linked loci
Hui et al.
Molecular Ecology Resources, 2021;
DOI: 10.1111/1755-0998.13412

28 Apr 2021
Population genomic evidence of Plasmodium vivax Southeast Asian origin
Daron et al.
Science Advances, 2021; 7(18) eabc3713
DOI: 10.1126/sciadv.abc3713

4 Mar 2020
Mapping the travel patterns of people with malaria in Bangladesh
Sinha et al.
BMC Medicine, 2020; 18(1) 45
DOI: 10.1186/s12916-020-1512-5

1 Mar 2020
Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain
van Dorp et al.
Molecular Biology and Evolution, 2020; 37(3) 773-785
DOI: 10.1093/molbev/msz264

18 Dec 2019
Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials
Peerawaranun P et al.
Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials, 2019; 18 428
DOI: 10.1186/s12936-019-3062-x

17 Jan 2019
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria
Llanos-Cuentas et al.
New England Journal of Medicine , 2019; 380(3) 229-241
DOI: 10.1056/NEJMoa1802537

17 Jan 2019
Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria
Lacerda et al.
New England Journal of Medicine, 2019; 380(3) 215-228
DOI: 10.1056/NEJMoa1710775

17 Dec 2018
Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka
Dewasurendra RL, Jeffreys A, Gunawardena SA, Chandrasekharan NV, Rockett K, Kwiatkowski D, & Karunaweera ND
Malaria Journal, 2018; 17 473
DOI: 10.1186/s12936-018-2622-9

4 Dec 2018
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
Zhu l, Tripathi J, Rocamora FM, Miotto O, Van der Pluijm R, Voss TS, Mok S, Kwiatkowski DP, Nosten F, Day NPJ, White NJ, Dondorp AM & Bozdech Z.
Nature Communications, 2018; 9 5158
DOI: 10.1038/s41467-018-07588-x

29 Nov 2018
A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways
Campino S, Marin-Menendez A, Kemp A, Cross N, Drought l, Otto TD, Benavente ED, Ravenhall M, Schwach F, Girling G, Manske M, Theron M, Gould K, Drury E, Clark TG, Kwiatkowski DP, Pance A & Rayner JC.
PLoS Pathogens, 2018; 4(11)
DOI: 10.1371/journal.ppat.1007436

25 Oct 2018
Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development
Duffy CW, Amambua-Ngwa A, Ahouidi AD, Diakite M, Awandare GA, Ba H, Tarr SJ, Murray l, Stewart lB, D'Alessandro U, Otto TD, Kwiatkowski DP & Conway DJ.
Scientific Reports, 2018; 8 15763
DOI: 10.1038/s41598-018-34078-3

19 Jul 2018
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B, Sepulveda N, Clark TG, Band G, Clarke G, Rowlands K, Hubbart C, Jeffreys A, Kariuki S, Marsh K, Mackinnon M, Maitland K, Kwiatkowski DP, Rockett KA & Williams TN.
The Lancet Haematology, 2018; 5
DOI: 10.1016/S2352-3026(18)30107-8

26 Jun 2018
Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia
Amambua-Ngwa A, Jeffries D, Amato R, Worwui A, Karim M, Ceesay S, Nyang H, Nwakanma D, Okebe J, Kwiatkowski D, Conway D & D'Alessandro U.
Scientific Reports, 2018; 8 9687
DOI: 10.1038/s41598-018-28017-5

25 Apr 2018
Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia
Opi DH, Swann O, Macharia A, Uyoga S, Band G, Ndila CM, Harrison EM, Thera MA, Kone AK, Diallo DA, Doumbo OK, lyke KE, Plowe CV, Moulds JM, Shebbe M, Mturi N, Peshu N, Maitland K, Raza A, Kwiatkowski DP, Rockett KA, Williams TN & Rowe JA.
eLife, 2018; 7
DOI: 10.7554/eLife.31579

29 Nov 2017
Genetic diversity of the African malaria vector Anopheles gambiae
The Anopheles gambiae 1000 Genomes Consortium
Nature, 2017;
DOI: 10.1038/nature24995

24 Jan 2017
Culture adaptation of malaria parasites selects for convergent loss-of-function mutants
Claessens, Affara et al.
Scientific Reports, 2017; 7 41303
DOI: 10.1038/srep41303

Learn more

19 Dec 2016
Extreme mutation bias and high AT content in Plasmodium falciparum
Hamilton, Claessens et al.
Nucleic Acids Research, 2016; pii gkw1259
DOI: 10.1093/nar/gkw1259

27 Jun 2016
Genomic analysis of local variation and recent evolution in Plasmodium vivax
Pearson et al
Nature Genetics, 2016; 48 959-964
DOI: 10.1038/ng.3599

Learn more

21 Jun 2016
Admixture into and within sub-Saharan Africa
Busby et al
eLife, 2016; 5:e15266
DOI: 10.7554/eLife.15266

Learn more

24 Mar 2016
Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies
Tripura R et al.
Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies, 2016; 15 181
DOI: 10.1186/s12936-016-1224-7

8 Mar 2016
The ethics of sustainable genomic research in Africa
Parker M, Kwiatkowski DP
Genome Biology, 2016; 17 44
DOI: 10.1186/s13059-016-0914-3

4 Mar 2016
Genomic epidemiology of artemisinin resistant malaria
MalariaGEN P. falciparum Community Project
eLife, 2016; 5 e08714
DOI: 10.7554/eLife.08714

Learn more

1 Oct 2015
A global reference for human genetic variation
1000 Genomes Project Consortium et al.
Nature, 2015; 526(7571) 68-74
DOI: 10.1038/nature15393

30 Sep 2015
A novel locus of resistance to severe malaria in a region of ancient balancing selection
Malaria Genomic Epidemiology Network
Nature, 2015; 526(7572) 253-257
DOI: 10.1038/nature15390

Learn more

15 Apr 2015
K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa
Kamau et al.
Journal of Infectious Diseases, 2015; 211(8) 1352-5
DOI: 10.1093/infdis/jiu608

26 Feb 2015
Malaria genomics: tracking a diverse and evolving parasite population
International Health, 2015; 7(2) 82-84
DOI: 10.1093/inthealth/ihv007

23 Feb 2015
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia
Mangano et al.
Journal of Infectious Diseases, 2015; 212(4) 626-34
DOI: 10.1093/infdis/jiv098

22 Feb 2015
G6PD gene variants and its association with malaria in a Sri Lankan population
Dewasurendra et al.
Malaria Journal, 2015; 14 93
DOI: 10.1186/s12936-015-0603-9

19 Jan 2015
Genetic architecture of artemisinin-resistant Plasmodium falciparum
Miotto et al
Nature Genetics, 2015; 47(3) 226-34
DOI: 10.1038/ng.3189

Learn more

15 Dec 2014
Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates
Ocholla et al.
Journal of Infectious Diseases, 2014; 210(12) 1991-2000
DOI: 10.1093/infdis/jiu349

28 Sep 2014
Reappraisal of known malaria resistance loci in a large multi-centre study
Rockett et al.
Nature Genetics, 2014; 46(11) 1197-204
DOI: 10.1038/ng.3107

18 Sep 2014
Optimized whole-genome amplification strategy for extremely AT-biased template
Oyola et al.
DNA Research, 2014; 21(6) 661-71
DOI: 10.1093/dnares/dsu028

12 Sep 2014
Monitoring parasite diversity for malaria elimination in sub-Saharan Africa
Ghansah et al.
Science, 2014; 345(6202) 1297-8
DOI: 10.1126/science.1259423

1 Sep 2014
Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia
Takala-Harrison et al.
Journal of Infectious Diseases, 2014; 211(5) 670-9
DOI: 10.1093/infdis/jiu491

31 Jul 2014
Spread of artemisinin resistance in Plasmodium falciparum malaria
Ashley et al.
New England Journal of Medicine, 2014; 371(5) 411-23
DOI: 10.1056/NEJMoa1314981

27 May 2014
Plasmodium falciparum founder populations in western Cambodia have reduced artemisinin sensitivity in vitro
Amaratunga et al.
Antimicrob Agents Chemother, 2014; 58(8) 4935-7
DOI: 10.1128/AAC.03055-14

28 Apr 2013
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Miotto et al
Nature Genetics, 2013; 45(6) 648-55
DOI: 10.1038/ng.2624

Learn more

24 Apr 2013
The genetic risk of acute seizures in African children with falciparum malaria
Kariuki et al.
Epilepsia, 2013; 54(6) 990-1001
DOI: 10.1111/epi.12173

7 Jun 2012
Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese
Dunstan SJ et al
Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese, 2012; 13(6) 503-8
DOI: 10.1038/gene.2012.25

18 Nov 2011
Ethical issues in human genomics research in developing countries
de Vries et al.
BMC Medical Ethics, 2011; 12 5
DOI: 10.1186/1472-6939-12-5

1 Feb 2010
Methodological challenges of genome-wide association analysis in Africa
Teo et al.
Nature Reviews Genetics, 2010; 11(2) 149-60
DOI: 10.1038/nrg2731

24 May 2009
Genome-wide and fine-resolution association analysis of malaria in West Africa
Jallow et al.
Nature Genetics, 2009; 41(6) 657-65
DOI: 10.1038/ng.388

11 Dec 2008
A global network for investigating the genomic epidemiology of malaria
Malaria Genomic Epidemiology Network
Nature, 2008; 456(7223) 732-7
DOI: 10.1038/nature07632

Learn more

24 Apr 2007
Valid consent for genomic epidemiology in developing countries
Chokshi et al.
PLoS Medicine, 2007; 4(4) e95
DOI: DOI: 10.1371/journal.pmed.0040095

23 Mar 2006
Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network
Taylor et al.
Transactions of the Royal Society of Tropical Medicine & Hygiene, 2006; 100(7) 615-22
DOI: doi: 10.1016/j.trstmh.2005.09.021