Studies of malaria immunity in Manteourou, Mali

Projects:

Locations: Mali (ML)

Partner study description

Researchers at the Malaria Research and Training Centre, University of Bamako contributed samples from individuals in rural villages in Manteourou county in the Dogon region of Mali. Malaria transmission is seasonal here, with most malaria occurring in the rainy season (June to October, EIR around 200 ib/p/year), and very little during the dry season (October to May).

The 976 samples contributed to Consortial Project 2 (CP2) come from three consecutive cross-sectional studies - two at the end of the transmission seasons of 2006 and 2007 respectively, and one during the dry season of 2007.

Study population

Dogon and Fulani live in sympatry in the study area and this is reflected in the sample composition (50% from each group). A distinct difference in malaria susceptibility between these two groups had been found in earlier studies, and was of special interest for CP2.

About half of the sample population are adults (> 15 years), and about a fifth of the children (≤ 15 years) are under the age of 5.

Morbidity and infection density

Infection with P. falciparum and P. malariae parasites was determined by inspection of blood smears on slides. Asexual (blood stage) and sexual (gametocyte) forms of the parasites were counted and parasite density calculated per microlitre of blood.

Clinical information

Clinical information, namely temperature and splenomegaly, were recorded for all individuals in this survey. For patients with malaria an assessment was also made as to whether the disease episode was symptomatic or asymptomatic. Of the 179 infected individuals, 86 (48%) were found to be symptomatic.

Key People

Prof Abdoulaye Djimdé
Associate Professor of Parasitology and Mycology; Chief of the Molecular Epidemiology and Drug Resistance Unit
Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Mali
Wellcome Trust International Fellow
Malaria Programme, Wellcome Trust Sanger Institute, UK
Amagana Dolo
Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Mali
Dr Boubacar Maiga
Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Mali
Marita Troye-Blomberg
Wenner-Gren Institute, University of Stockholm, Sweden
Prof Ogobara Doumbo
Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Mali
Ousmane Boubacar Toure
Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Mali