1179 Targeted Chemo-elimination (TCE) of Malaria (TME)

Targeted Malaria Elimination (TME) studies took place in western Myanmar, Vietnam, Cambodia, and Laos during 2013-17, led by the Mahidol-Oxford Tropical Medicine Research Unit. This project consisted of 2 stages. Firstly, multiple malaria prevalence surveys and collection of treatment records to define the epidemiology of the asymptomatic reservoir, infection risk factors, prevalence of simian malarias, and spatio-temporal mapping. Secondly, a controlled clinical trial of mass drug administration which successfully interrupted falciparum transmission. MORU’s project was funded by the Wellcome Trust and the Bill and Melinda Gates Foundation.

Publications

• Mass drug administration for the acceleration of malaria elimination in a region of Myanmar with artemisinin-resistant falciparum malaria: a cluster-randomised trial
  McLean ARD et al
  The Lancet Infectious Diseases, 2021; 21 1579
  10.1016/S1473-3099(20)30997-X
• Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials
  Phommasone K et al.
  PloS One, 2020; 15 e0228190
  10.1371/journal.pone.0228190
• Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials
  Peerawaranun P et al.
  Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials, 2019; 18 428
  10.1186/s12936-019-3062-x
• The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial
  von Seidlein L et al
  PLOS Medicine, 2019; 16 e1002745
  10.1371/journal.pmed.1002745
• Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: A pilot trial in four villages of Eastern Myanmar
  Landier J et al
  Wellcome Open Research, 2017; 2 81
  10.12688/wellcomeopenres.12240.1
• Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies
  Tripura R et al.
  Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies, 2016; 15 181
  10.1186/s12936-016-1224-7