Previously archived samples of Anopheles have been collected as part of the Senegalese PMI  Project, providing data on spatial and temporal changes in the vector populations’ dynamics, susceptibility to insecticide, P. falciparum infection rates and host preference.

However, except for the kdr genes, genetic changes have not been addressed to date despite   the pronounced impact that the strong selection exerted by increasing indoor residual spraying and bed-net coverage is expected to have created. This study aims to provide a valuable archive to supplement investigations into temporal changes at the genomic and population genetic/genomic levels, induced by anthropogenic activities. In addition, this study samples from a range of contrasting ecological zones that potentially present natural barriers to dispersal that may impact gene flow, and different selective environments for adaptation.

Notably, this study focuses on An. arabiensis , due to its wide distribution range across the country and An. gambiae and An. coluzzii samples are collected incidentally.

Contributors:

• El Hadji Amadou Niang: Laboratoire d’Ecologie vectorielle et Parasitaire, Université Cheikh Anta Diop de Dakar, Sénégal
• David Weetman: Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK
• Lassana Konaté: Laboratoire d’Ecologie vectorielle et Parasitaire, Université Cheikh Anta Diop de Dakar, Sénégal
• Beniamo Caputo: Parasitology Unit, Department of Public Health and Infectious Diseases, Università di Roma La Sapienza, Italy
• Badara Samb: Laboratoire d’Ecologie vectorielle et Parasitaire, Université Cheikh Anta Diop de Dakar, Sénégal
• Ousmane Faye: Laboratoire d’Ecologie vectorielle et Parasitaire, Université Cheikh Anta Diop de Dakar, Sénégal