1022 Genome variation and selection in clinical isolates from rural Malawi


Locations: Malawi (MW)

Partner study description

As part of his PhD research Harold Ocholla worked with colleagues at the Liverpool School of Tropical Medicine and in Malawi to collect uncultured paediatric Plasmodium falciparum isolates from malaria patients in a region of high malaria transmission in the Chikwawa and Zomba districts of Malawi over multiple malaria seasons. The goal of his work is to map genome variation and genetic signatures of evolutionary selection in these parasite populations in space and time, to identify associations between genetic variants and important clinical malaria phenotypes.

Key People

Prof Alister Craig
Professor of Molecular Parasitology and Dean of Biological Sciences
Liverpool School of Tropical Medicine, UK
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Malawi
Dr Harold Ocholla
Malaria Capacity Development Consortium
KEMRI - Centres for Disease Control and Prevention (CDC) Research Program, Kisumu, Kenya
Centre for Bioinformatics and Biotechnology, University of Nairobi, Kenya
Jacqui Montgomery
World Mosquito Program, Monash University, Australia
Malawi-Liverpool-Wellcome Trust Clinical Research Program, Blantyre, Malawi
Brigitte Denis
Malawi-Liverpool Wellcome Trust Clinical Research Programme, Malawi