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P. falciparum Community Project

Started 2010

Parasite
 

Introduction

The P. falciparum Community Project provides researchers with high-quality genotypes linked to a global resource characterising genetic variation in P. falciparum populations.

Objectives & Coordination

The P. falciparum Community Project connects multiple research groups, each acquiring data on parasite genome variation — often in different geographical locations and for different scientific reasons. Working with this community, our long-term goal is to generate accessible information to improve malaria control.

The project is managed by the MalariaGEN Resource Centre. See the P. falciparum Community Project description for more information on the project structure, and data release and publication policies.

Our work is focused on four related objectives:

Building a catalogue of variation and allele frequencies

By aggregating data across many samples, we’re able to identify thousands of variations with a high-level of confidence and estimate their frequencies in different groups of samples. We’re building a catalogue of variation in the P. falciparum genome based on sequence data analysis, together with estimated allele frequencies in different geographical regions based on aggregated analysis of all the samples and data that have been contributed.

The catalogue is updated periodically — as the number of samples increases, as we incorporate data from different locations, and as sequencing technologies and analytical methods improve.

Providing researchers with standardised genotype data on their samples

Our sequence data analysis pipeline provides researchers with high-quality genotype calls on their samples in a standardised format which enables reliable comparisons to be made with data from other studies and geographical locations.

Publishing global analyses of genome variation, population genetics and evolutionary selection

We’ll report on the major geographical divisions of parasite population structure and use this to calculate allele frequency data, as well as analysing other aspects of genome variation, population genetics and evolutionary selection that can best be achieved using the aggregated dataset. These global analyses will be reported through peer-reviewed publications subject to the agreement of the groups who have contributed samples and data. Where appropriate, this will be done through mechanisms such as the Pf3k Project that bring together expert working groups and integrate multiple sources of data to produce specific analytical outputs.

Creating online tools to maximise the reach and impact of project findings

We’ve developed a set of web tools to enable contributing researchers to explore and analyse sequence read data and genotype calls on their own samples. We have also partnered with the MRC Centre of Genomics and Global Health to build a comprehensive web application to provide the wider research community with user-friendly tools to browse and query project data (http://www.malariagen.net/apps/pf).

Sampling locations

Bangladesh, Benin, Burkina Faso, Cambodia, Cameroon, Colombia, Congo, Ethiopia, The Gambia, Ghana, Guinea, Indonesia, Ivory Coast, Kenya, Laos, Madagascar, Malawi, Mali, Mauritania, Myanmar, Nigeria, Papua New Guinea, Peru, Senegal, Tanzania, Thailand, Uganda, Vietnam.

Data

We routinely release genotype data to our partners.

We routinely release genotype data to our partner studies; in addition, we periodically release public access datasets.

Learn more about data release to partners.

Current

8 Dec 2022 Pf7: An open dataset of Plasmodium falciparum - v.7.0
Species: P. falciparum

Sample information for 20,864 samples from 33 countries

Open access

13 Nov 2020 Catalogue of Genetic Variation in P. falciparum - v6.0
Species: P. falciparum

Sample information for 7,113 samples from 29 countries
Genotypes for 5,970 samples from 29 countries

ENA Accessions, Genotype data, Sample metadata, SNPs

Open access

15 Jan 2016 P. falciparum Community Project Jan. 2016 data release
Species: P. falciparum

Sample information for 3,411 samples from 23 countries
Genotypes for 3,394 samples from 22 countries

This data is
Open access

Archived

19 Aug 2015 Catalogue of Genetic Variation in P. falciparum - v4.0
Species: P. falciparum

Sample set: 3,488 samples from 23 countries

High-quality SNPs: 900,000+

Manuscript on bioRxiv
Open access

Archived

19 Jan 2015 P. falciparum sample information
Species: P. falciparum

Sample information for P. falciparum samples and sequence data included in previous published population-level analyses

This data is
Open access

Archived

27 Feb 2014 Catalogue of Genetic Variation in P. falciparum - v3.1
Species: P. falciparum

Sample set: 3,251 samples from 20 countries

High-quality SNPs: 681,587

Partner data release (v5.1)
Open access

Archived

26 Sep 2013 Catalogue of Genetic Variation in P. falciparum - v2.2
Species: P. falciparum

Sample set: 2,155 samples from 19 countries

High-quality SNPs: 531,916

Partner data release (v5.0)
Open access

Archived

22 May 2012 Catalogue of Genetic Variation in P. falciparum - v1.0
Species: P. falciparum

Sample set: 227 samples from 6 countries

High-quality SNPs: 86,000

Partner data release (v4.0)
Open access

Archived

For partners

Resources for partners working on parasites

Partner studies

We work with a number of researchers undertaking independent studies to address unique questions about malaria biology and disease in malaria endemic areas. Each study is different, but they all involve a genomic component whereby they partner with us to sequence parasite samples and share the population genetic data. Click a link below to learn more about their work.

11 Nov 2015 1001 Developing the Community Project with partners in Mali

Partner study description Abdoulaye Djimde and his colleagues worked with MalariaGEN to collect clinical parasite samples from three sites in Mali: Bamako, the capital, and Kolle and Faladje, rural villages approximately 60km and…

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11 Nov 2015 1004 Developing the Community Project with partners in Burkina Faso

Partner study description In Burkina Faso, Jean-Bosco Ouedraogo and his colleagues worked with the MalariaGEN team to collect samples from three urban clinics in Bobo-Dioulasso – Colsama, Ouezzin-ville and Sakaby – each up…

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11 Nov 2015 1006 Genome-wide analysis of genetic variation in The Gambia

Partner study description Alfred Amambua-Ngwa, David Conway, and colleagues surveyed clinical Plasmodium falciparum isolates from The Gambia to assess several measures of genetic variation including allele frequency spectra and signatures of balancing selection,…

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11 Nov 2015 1007 Mother Offspring Malaria Study (MOMS) in Tanzania

Partner study description Led by Patrick Duffy, the Mother Offspring Malaria Study (MOMS) aims to understand the relationship between parasite phenotype and clinical outcomes, and to identify parasite ligands and soluble mediators involved…

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11 Nov 2015 1008 Containment of artemisinin tolerant malaria parasites in Southeast Asia (ARCE)

Partner study description ARCE is a WHO-lead strategy for the containment of artemisinin resistant parasites in Southeast Asia, aiming to ultimately contribute to the elimination of falciparum malaria from the area. Samples collected…

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11 Nov 2015 1010 Genetic variation underlying drug resistance at the Thai-Burmese border

Partner study description In one of the first partnerships of the MalariaGEN P. falciparum Community Project, Timothy Anderson and colleagues used whole genome sequencing and genotyping to identify genetic variants that underpin drug…

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11 Nov 2015 1011 Genome-wide scans of culture adapted parasites in Cambodia

Partner study description Xin-zhuan Su and colleagues provided samples from their field site in Pursat province, Cambodia at an early stage in the MalariaGEN P. falciparum Community Project. These samples were contributed to…

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11 Nov 2015 1012 Developing the Community Project with partners in Cambodia

Partner study description Several investigators contributed to the early stages of the MalariaGEN P. falciparum Community Project by providing samples that were not themselves the basis of a partner study, but were used…

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11 Nov 2015 1013 Developing the Community Project with partners in Peru

Samples from Zungarococha, Peru were collected in 2005-6 as part of the Malaria Immunology and Genetics in the Amazon (MIGIA) project. Malaria caused by Plasmodium falciparum emerged near the Amazonian city of Iquitos…

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11 Nov 2015 1014 Analysis of Plasmodium falciparum samples from UK travellers returning from malaria endemic countries

Partner study description In collaboration with Colin Sutherland and Tim Robinson, we sequenced samples obtained from travellers returning to the UK from malaria-endemic countries being treated for clinical malaria in the Hospital for…

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11 Nov 2015 1015 Genome-wide association study of in vitro drug resistance in Kenya

Partner study description As a part of clinical studies being undertaken by the KEMRI-Wellcome Trust Research Programme, samples were collected in the Kilifi district of Kenya. Alexis Nzila and his colleagues adapted these…

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11 Nov 2015 1016 Developing the Community Project with partners in Thailand

Partner study description Several investigators contributed to the early stages of the MalariaGEN P. falciparum Community Project by providing samples that were not themselves basis of a partner study, but were used in…

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11 Nov 2015 1017 Population genetics of natural populations in Northern Ghana

Partner study description In collaboration with colleagues at the Navrongo Health Research Center, Dr Lucas Amenga-Etego conducted his thesis research under the guidance of Prof Dominic Kwiatkowski on genetic diversity in natural populations…

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11 Nov 2015 1020 Measuring in vitro drug sensitivity in Vietnam

Partner study description Samples were collected in the southern province of Binh Phuoc, Vietnam, as part of a set of clinical studies initiated by Professor Tran Tinh Hien and Christiane Dolecek in 2009…

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11 Nov 2015 1021 Building a national repository of malaria isolates in Papua New Guinea

Partner study description Samples from Papua New Guinea were collected as part of ongoing malaria surveillance efforts to build a national repository of malaria isolates. Some of these samples were obtained as part…

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11 Nov 2015 1022 Genome variation and selection in clinical isolates from rural Malawi

Partner study description As part of his PhD research Harold Ocholla worked with colleagues at the Liverpool School of Tropical Medicine and in Malawi to collect uncultured paediatric Plasmodium falciparum isolates from malaria…

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11 Nov 2015 1023 Comparative analysis of permeome genes and drug resistance in Colombia

Partner study description Colombia is among the countries with the highest malaria burden outside of Africa, and one of the least successful in reducing case numbers, with approximately 100,000 cases per year. The…

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11 Nov 2015 1024 FightMal - Correlating protection from malaria with immune profile of infected individuals in Uganda

This study aims to correlate protection from malaria with the immune profile of infected individuals. Cross-sectional and longitudinal studies were conducted in all-age cohorts living in Apac, northern Uganda. This area is characterised…

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11 Nov 2015 1026 Effects of transmission intensity on population structure and signatures of selection in Guinea

Partner study description This study was designed to identify malaria parasite genes under selection in the highly endemic forested area of southern Guinea, where very few studies on malaria have been conducted previously.…

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11 Nov 2015 1027 Genomics of severe malaria and low host immunity in Kenya

Partner study description Plasmodium falciparum var genes are a large and diverse gene family that encode PfEMP1, an important set of antigenic virulence molecules that are inserted into the surface of parasite erythrocytes.…

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11 Nov 2015 1031 Artemisinin Resistance Confirmation, Characterization and Containment (ARC3)

Partner study description ARC3, an international collaboration led by the World Health Organization, supported clinical trials of artesunate monotherapy in Cambodia, Thailand and Bangladesh. ARC3 aimed to confirm clinical resistance to artemisinin in…

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11 Nov 2015 1044 Genomics of parasite clearance and recrudescence rates in Cambodia

Partner study description In field-based studies, Rick Fairhurst and colleagues investigated patient responses to artemisinin combination therapies (ACTs), in three Cambodian provinces, where artemisinin resistance is entrenched (Pursat), emerging (Preah Vihear), or uncommon…

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21 Nov 2015 1052 Tracking Resistance to Artemisinin Collaboration (TRAC)

Partner study description TRAC is investigating the scope and spread of parasite resistance to artemisinin-based therapies at sites across Asia and Africa. The first TRAC study has been completed. This multi-centre, open-label randomised…

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21 Nov 2015 1062 Understanding malaria parasite populations and outbreaks in Papua New Guinea

Partner study description Microsatellite analysis has previously demonstrated that Plasmodium falciparum populations on the north coast of PNG are organised into distinct subpopulations. If this pattern is observed throughout PNG, maps of population…

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21 Nov 2015 1083 Alternative molecular mechanisms for erythrocyte invasion by Plasmodium falciparum in Ghana

Partner study description The intensity of malaria transmission varies considerably among sites in Ghana due to differences in average temperatures, rainfall patterns, and urbanization. This study has selected two locations that have among…

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21 Nov 2015 1093 Population genetics of Plasmodium falciparum parasites in South-Western Cameroon

Partner study description Tobias Apinjoh is using whole genome sequencing to investigate the genetic diversity present in natural populations of Plasmodium falciparum parasites collected in different micro-ecological zones along the slope of Mount…

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21 Nov 2015 1094 Population genetics of Plasmodium falciparum parasites in Northern Ghana

Partner study description In collaboration with colleagues at the Navrongo Health Research Center, Lucas Amenga-Etego is investigating the genetic diversity and population structure of Plasmodium falciparum parasites collected in the Kassena-Nankana districts of…

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23 Feb 2022 1095 Genome variation and its affect on ACT treatment outcome in Tanzania

Partner study description This study aims to assess the diversity of Plasmodium falciparum in regions of varying endemicity in Tanzania, and to investigate parasite genetic factors which might affect antimalarial treatment outcome among…

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8 Jan 2020 1096 Population genetics of Plasmodium falciparum parasites in Southern Ghana

Partner study description Anita Ghansah is investigating the population diversity and genetic structure of Plasmodium falciparum parasites collected from Cape-Coast in the coastal savanna zone of Ghana. The overall objective is to build…

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8 Jan 2020 1097 Detection of artemisinin-resistant Plasmodium falciparum parasites in Southern Mali

Partner study description Abdoulaye Djimdé at the Malaria Research and Training Centre at the University of Bamako and Oumou Maïga-Ascofaré are investigating the genetic signature of drug pressure on Plasmodium falciparum parasites collected…

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8 Jan 2020 1098 The prevalence of asymptomatic carriage; emergence of parasite mutations conferring anti-malaria drug resistance; and G6PD deficiency in the human population, as possible impediments to malaria elimination in Ethiopia

Partner study description Since 2004, Ethiopia has adopted a species-specific treatment policy for malaria: artemether-lumefantrine (AL) for the treatment of uncomplicated Plasmodium falciparum malaria and chloroquine (CQ) for Plasmodium vivax infections. P. falciparum…

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8 Jan 2020 1100 Drug resistance and Plasmodium falciparum diversity in forest zone of Côte d’Ivoire

Partner study description William Yavo is investigating Plasmodium falciparum parasite population structures according to epidemiological facies and their impact on artemisinin combination therapy (ACT) treatment failure. Samples of the parasites were collected in…

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21 Nov 2015 1101 Efficacy of three ACTs in treating falciparum malaria in the Democratic Republic of Congo

Partner study description This clinical study aims to assess the efficacy of amodiaquine-artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in children in Kinshasa, DRC, five years after its introduction as a…

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21 Nov 2015 1102 Genotyping Plasmodium falciparum and Plasmodium vivax in Madagascar

Partner study description The island of Madagascar is geographically situated in the south western region of the Indian Ocean and amongst malaria-endemic countries, its situation is unique: historically, human migration has occurred from…

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8 Jan 2020 1103 Population genetics of cross-border Plasmodium falciparum parasites in West Africa

Partner study description In collaboration with colleagues at the MRC Unit The Gambia, Alfred Amambua Ngwa is investigating the population structure and signatures of selection from immunity and drugs in isolated and cross-border…

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8 Jan 2020 1107 Population genetics of Plasmodium falciparum parasites in Kenya

Partner study description Together with colleagues at the United States Army Medical Research Directorate in Kenya, Edwin Kamau is investigating population structure and signals of selection from anti-malarial drug resistance of Plasmodium falciparum…

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23 Feb 2022 1108 Determining parasite genetic diversity in Gabon

Partner study description This study collected Plasmodium falciparum samples in Gabon for genomic sequencing. This study is contributing to the Plasmodium Diversity Network Africa (PDNA), an African-led network investigating the genetic diversity and…

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22 Jun 2021 1114 Surveillance of kelch-13 mutation in Ghana

Anita Ghansah is investigating Plasmodium falciparum genomic population structure in Ghana, specifically monitoring for occurrence of the kelch-13 mutation, known to confer drug resistance in South East Asia. This study is contributing to…

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21 Nov 2015 1125 Investigating artemisinin resistance emergence on Thai-Burmese border

Partner study description Plasmodium falciparum resistance to artemisinin derivatives emerged on the Thai Myanmar border between 2000 and 2010. The Shoklo Malaria Research Unit (SMRU) has collected phenotypic data on more than 3,000…

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8 Jan 2020 1127 Genetic analysis of Plasmodium falciparum before and after artemether-lumefantrine treatment in Mali

Partner study description Although artemisinin combination therapy (ACT) resistance has not yet been found in Mali, previous studies have shown that cases of recurring Plasmodium falciparum parasites within a month of infection after…

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8 Jan 2020 1131 Identification of virulence factors in cerebral malaria in Benin

Partner study description Gwladys Bertin is interested to facilitate the identification of variants associated to cerebral malaria in the proteomic analysis. She is correlating proteomic data from cerebral malaria samples with whole genome…

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23 Feb 2022 1132 Using whole genome sequence data to analyse the spatio-temporal genetic diversity of malaria parasites in Kilifi, Kenya

Partner study description Effective control and final elimination of malaria in the face of declining transmission and increasing spatial heterogeneity of disease and infection will require the identification and targeting of hotspots or…

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8 Jan 2020 1134 Population genetics of Plasmodium falciparum in West Africa

Partner study description This project has involved studying the population genomics of malaria parasites in Mali, to compare the signatures of selection in the parasite genome with patterns seen elsewhere in West Africa.…

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8 Jan 2020 1135 Parasite adaption in Senegal at molecular, functional and population level

Partner study description This project has involved studying the population genomics of malaria parasites in an area of low infection endemicity in Senegal, to compare the signatures of selection in the parasite genome…

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8 Jan 2020 1136 Plasmodium falciparum anti-malarial drug resistance in The Gambia: Identification of potential genetic markers by retrospective whole genome approaches

Partner study description In The Gambia, malaria transmission has substantially declined in the last 5-10 years and access to treatment is good. The relatively high drug pressure, reduced transmission and consequent waning of…

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8 Jan 2020 1137 Malaria transmission dynamics in The Gambia: Defining the spatial and temporal spread of malaria at micro-level (village)

Partner study description The overall objective of this study is to understand the determinants of malaria heterogeneity and the spatial and temporal spread of malaria infections. Alfred Amambua Ngwa and Umberto d’Alessandro plan…

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8 Jan 2020 1138 Parenteral artesunate compared to quinine as a cause of late post-treatment anaemia in African children with hyperparasitaemic Plasmodium falciparum malaria (DHART)

Partner study description Caterina Fanello and colleagues investigated the incidence of late onset anaemia in children with uncomplicated hyperparasitemic Plasmodium falciparum malaria treated with intravenous (IV) artesunate or IV quinine. Two blood samples…

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23 Feb 2022 1140 PfSPZ phase I trial in Doneguebougou, Mali

Partner study description This study is a phase I clinical trial to evaluate the safety of repeated intravenous (IV) immunizations with irradiated Plasmodium falciparum sporozoites (PfSPZ) in African adults. In collaboration with Sanaria…

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8 Jan 2020 1141 Genomic characterization of Plasmodium falciparum from asymptomatic infections in The Gambia

Partner study description The dry season in The Gambia presents a bottleneck for the total parasite population as there is little or no malaria transmission. Some individuals maintain a malaria infection through this…

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8 Jan 2020 1145 Genotype-phenotype study of erythrocyte invasion in Peruvian Plasmodium falciparum isolates

Partner study description Dionicia Gamboa, Joseph Vinetz and colleagues are analysing Peruvian Plasmodium falciparum host-parasite interactions during invasion of the parasite into the human red blood cell. Samples for this study were collected…

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21 Nov 2015 1146 Characterisation of drug resistance in Plasmodium falciparum populations

Partner study description Ric Price and Rintis Noviyanti are the principal investigators in a genome-wide study aiming to characterise the molecular profile of drug resistance-conferring variants in Indonesian Plasmodium falciparum populations. The study…

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9 Jan 2020 1147 Population genetics of Plasmodium falciparum parasites in Mauritania

Partner study description This project is led by the London School of Hygiene and Tropical Medicine and the Institut National de Recherches en Santé Publique (INRSP), Mauritania, and supported by an MRC Project…

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26 May 2021 1148 Assessing the contribution of migration to the emergence and spread of antimalarial drug resistance in Southeast Bangladesh

This study measured population movement by travel surveys and mobile phone call record data and combined these with parasite genotype data and malaria incidence to examine the role of population movement on the…

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4 Apr 2022 1149 Treatment Efficacy Studies in Myanmar

Partner study description Treatment Efficacy Studies are conducted routinely in Myanmar, to assess the efficacy of frontline treatments. Dried bloodspot (DBS) samples for this study were collected from patients at multiple sites from…

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9 Jan 2020 1151 Testing the effectiveness of selective whole genome amplification on samples collected in Northern Ghana

Partner study description For this study, Lucas Amenga-Etego and colleagues collected dried blood spot (DBS) and venous blood samples from patients in the Navrongo Health and Demographic surveillance area in the Upper East…

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22 Jun 2021 1162 Genomic variation and antimalarial resistance evolution in The Gambia

In terms of malaria prevalence, The Gambia can be divided into two strata: low prevalence in the western part and relatively high prevalence in the eastern part. Nevertheless, within these two strata, prevalence…

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22 Jun 2021 1164 Plasmodium falciparum clearance times in Malian villages following artesunate monotherapy

A multicentre study to evaluate the in vivo, in vitro and molecular efficacy of artesunate in monotherapy for the uncomplicated malaria treatment is currently running in two study sites in Mali; Bougoula-hameau, at…

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22 Jun 2021 1165 Prevalence of gene polymorphisms in symptomatic and asymptomatic Plasmodium falciparum infected individuals from the Southwest region of Cameroon

The study was conducted in localities on the eastern slope of Mt Cameroon, with varying malaria transmission profiles and geographic features. The terrain rises from the Atlantic ocean at the Gulf of Guinea,…

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23 Feb 2022 1167 Surveillance of parasite populations and patterns of drug resistance, and associated parasite clearance or treatment failure in Tanzania

Partner study description Artemether-lumefantrine (AL) is the recommended first-line artemisinin-based combination therapy (ACT) for the treatment of uncomplicated falciparum malaria in most of the malaria-endemic countries, including Tanzania. Recently, dihydroartemisinin-piperaquine (DP) has been…

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22 Jun 2021 1168 Genomic surveillance of Plasmodium falciparum in the Kassena-Nankana Districts, Ghana

In the Kassena-Nankana Districts (KNDs) malaria is highly endemic with marked seasonal variation in transmission intensity. The high transmission season coincides with the rainy season, which is from July to October and low…

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22 Jun 2021 1169 Using genomic sequencing to diminish the malaria burden in the Pacific coast of Colombia

This study aims to use genome-wide sequencing to establish the structure of Plasmodium populations in an endemic area of low malaria transmission with occasional outbreaks, in the Pacific region of Colombia, and analyse…

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25 May 2021 1180 Tracking Artemisinin Resistance Collaboration (TRAC II) with SpotMalaria

A multi-centre, open-label randomized trial to assess the efficacy, safety and tolerability of Triple Artemisinin-based Combination Therapies (TACTs) compared to Artemisinin-based Combination Therapies (ACTs) in uncomplicated falciparum malaria and to map the geographical…

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26 May 2021 1181 Monitoring the susceptibility of Plasmodium falciparum to antimalarial drugs in malaria endemic areas in southern Vietnam

Routine monitoring of the efficacy of anti-malarial drugs used is necessary for effective case management, early detection of drug resistance and to provide background information for the development and evaluation of drug policies.…

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22 Jun 2021 1182 Understanding the determinants of malaria heterogeneity and the spatial and temporal spread of malaria in The Gambia

In terms of malaria prevalence, The Gambia can be divided into two strata: low prevalence in the western part and relatively high prevalence in the eastern part. Nevertheless, within these two strata, prevalence…

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23 Feb 2022 1183 Alternative mechanisms for erythrocyte invasion by Plasmodium falciparum

Partner study description This study looks at samples collected from two sites in Ghana. The first is Lekma Hospital, Teshie, Accra; near the coast, an eastern suburb of Accra. Malaria transmission in Teshie…

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22 Jun 2021 1185 Ancient Western Cambodian Plasmodium falciparum isolates

One difficulty in understanding the epidemiology of drug resistance in Cambodia is that we have little notion of what an “original” Western Cambodian parasite looked like, before the founder populations emerged. Five CB…

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23 Feb 2022 1192 Genomic surveillance of Plasmodium falciparum in Mali

Partner study description This study collected Plasmodium falciparum dried blood spot samples in Mali for genomic sequencing between 2016 and 2018.

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23 Feb 2022 1195 Tracking Artemisinin Resistance Collaboration (TRAC II)

Partner study description A multi-centre, open-label randomized trial to assess the efficacy, safety and tolerability of Triple Artemisinin-based Combination Therapies (TACTs) compared to Artemisinin-based Combination Therapies (ACTs) in uncomplicated falciparum malaria and to…

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23 Feb 2022 1197 Multidisciplinary research for malaria control and prevention in Mali

Partner study description This study looked at different field sites in Mali representing three different major eco-zones across West Africa that are different with regard to endemicity and current implementation of control strategies:…

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22 Jun 2021 1198 Malaria Elimination Task Force

The objectives of this programme were to scale-up the targeted mass drug administration strategy regionally, and measure its effect on the incidence of clinical malaria in eastern Karen/Kayin state, Myanmar, a difficult-to-access hilly…

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23 Feb 2022 1199 Developing SpotMalaria with partners in Mali

Partner study description A small number of Plasmodium falciparumsamples collected in Mali that were contributed to support the set-up of the SpotMalaria platform.

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23 Feb 2022 1200 Genomic surveillance of Plasmodium falciparum in the Ashanti region of Ghana

Partner study description This study collected Plasmodium falciparum samples in the Ashanti region of Ghana for genomic sequencing.

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1202 Determining the Burden of Plasmodium falciparum malaria in Sabah State

1) An ongoing state-wide malaria surveillance study in Sabah, Malaysia funded through NIH and Australian NHMRC. All patients presenting to government health facilities with symptoms of malaria and microscopically confirmed Plasmodium species (with…

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26 May 2021 1207 Integrating genetic epidemiology as an intensified surveillance tool into the National Center for Parasitology Entomology and Malaria Control of Cambodia

Genetic surveillance project conducted by the National Malaria Control Programme in partnership with GenRe-Mekong in endemic regions of Cambodia. This is part of a large project of genetic surveillance of malaria in the…

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26 May 2021 1208 Genetic epidemiology of Plasmodium falciparum malaria and associated antimalarial drug resistance in Lao PDR

Genetic surveillance project conducted by the National Malaria Control Programme in partnership with GenRe-Mekong in endemic region of the Lao PDR. This is part of a large project of genetic surveillance of malaria…

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26 May 2021 1209 Genetic epidemiology of Plasmodium falciparum malaria and associated antimalarial drug resistance in Central Vietnam

Genetic surveillance project conducted by the National Malaria Control Programme in partnership with GenRe-Mekong in endemic region of Vietnam. This is part of a large project of genetic surveillance of malaria in the…

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25 May 2021 1210 Epidemiology of malaria in northeast Thailand: a case-control study

This study aimed to determine risk factors for catching malaria in northeast Thailand, including travel, to identify where people were likely being infected and determine how much antimalarial drug resistance there is.

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22 Jun 2021 1223 Evaluation of intermittent preventive treatment during pregnancy (IPTp) in Chókwè district, Southern Mozambique (acronym IPTpCHOKWE)

Malaria during pregnancy is an important cause of maternal and fetal morbidity and mortality. In compliance with WHO recommendations, Mozambique introduced intermittent preventive treatment with Sulfadoxine/Pyrimethamine (IPTp-SP) as standard of care for malaria…

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22 Jun 2021 1224 Identification of molecular mechanisms of ACT treatment failure in Vietnam

This study is a country-wide retrospective analysis of molecular markers with potential impact on resistance before and after ACT introduction (18-year period).

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1 Jun 2023 1226 Molecular characterization of drug resistance in Plasmodium falciparum

Partner study description A prospective study designed to identify molecular markers of antimalarial drug resistance in Plasmodium falciparum in Yola, Nigeria. Objectives of the study are: To detect clinically significant genes associated with…

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28 Nov 2022 1227 Plasmodium falciparum surveillance in Peru, Colombia and Honduras

This study and the adjoined Plasmodium vivax study 1250 collectively form a project aimed towards providing genetic and clinical data of circulating P. falciparum and P. vivax populations in different endemic regions in…

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22 Jun 2021 1233 Epidemiology of kelch13 mutants in Papua New Guinea

The spread of artemisinin-resistant kelch13 mutants in Southeast Asia (in particular the prevalent C580Y strain) gives cause of concern in view of the possibility these strains may migrate to neighbouring regions, such as…

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1 Jun 2023 1234 Genetic analysis of Plasmodium falciparum in Mozambique

Partner Study Description As countries decrease malaria transmission and come closer to elimination, transmission becomes more fragmented and focal, and human population movement becomes an important factor in the spread of infection. Proper…

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25 May 2021 1238 Research on malaria molecular and genomic epidemiology in all drug-resistance regions of Vietnam: case-control research on the risk factors

Genetic surveillance project conducted by the National Malaria Control Programme in partnership with GenRe-Mekong in endemic regions of Vietnam. The study aimed to determine risk factors for catching malaria in high endemic areas…

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25 May 2021 1239 Targeted Malaria Elimination in Chey Saen District, Preah Vihear Province, Cambodia

Given the emergence of Plasmodium falciparum (Pf) artemisinin resistance Médecins sans Frontières launched in May 2014 a research programme in Chey Saen district (Cambodia), aimed at preventing its spread. The activities of passive…

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22 Jun 2021 1241 Viability and pathogenicity of Plasmodium spp in infected blood donor units and immunological and genetic markers associated with malaria infections

The main aim of the study shall be to determine the viability and the pathogenicity of Plasmodium falciparum in donor blood units during storage under standard conditions (2-8ᵒC). Specifically, the study has been…

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20 Apr 2022 1247 Surveillance of antimalarial drug resistance related genes in Plasmodium falciparum in Sudan

Partner study description This is a cross sectional and screening study to determine the prevalence of drug resistant alleles in Sudanese Plasmodium falciparum field isolates which has been collected from different areas in…

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1254 Implementing a differential molecular diagnostic platform and Information and Communication technologies (ICTs) for the surveillance of Zika, Dengue, Chikungunya and Malaria: Pilot Study

The main objective of this pilot project was to determine the co-transmission of Malaria, Dengue, Zika and Chikungunya in the Peruvian Amazon (Iquitos) and North coast (Piura) using a differential diagnosis by molecular…

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8 Sep 2022 1262 Randomized trial to assess the safety, tolerability and efficacy of arterolane-piperaquine, arterolane-piperaquine+mefloquine and artemether-lumefantrine

Partner study description Randomized trial to assess the safety, tolerability and efficacy of arterolane-piperaquine, arterolane-piperaquine+mefloquine and artemether-lumefantrine. Number of subjects 219. We obtain parasite clearance half lives and travel surveys.

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18 Aug 2022 1263 Genotyping of Antimalarial Resistance Markers from Dried Blood Spot

Resistance of Plasmodium species to previous generations of medicines, such as chloroquine and sulfadoxine-pyrimethamine (SP), influenced the replacement of chloroquine (CQ) with sulfadoxine-pyrimethamine (SP) then artemisinin-based combination therapy (ACT) for treatment of malaria…

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31 May 2023 1268 Pan-African Malaria Genetic Epidemiology Network (PAMGEN) Plasmodium falciparum samples

Partner study description The Plasmodium falciparum samples due to be collected from seven countries (The Gambia, Ghana, Mali, Cameroon, Ethiopia, Tanzania and Madagascar) will contribute to the Pan-African Malaria Genetic Epidemiology Network (PAMGEN)…

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1282 Malaria molecular epidemiology in West Equatoria, South Sudan

The study is the operational research component of a larger project funded by the Global Fund 5% Initiative through the Italian Agency of Development Cooperation. The project title is “Enhancement of Malaria response…

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21 Jun 2022 1283 Malaria Drug Resistance Molecular Markers of Plasmodium falciparum in Sudan

Malaria remains a major public health problem in Sudan and worldwide. One of the major problems hindering the efforts to combat malaria is the emergence of drug resistant parasites and the subsequent treatment…

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21 Sep 2022 1294 Investigation of Host and Parasite Genetic Factors Mediating asymptomatic Plasmodium falciparum infections

Partner study description As part of his PhD project, Collins Morang’a collected asymptomatic and symptomatic individuals during the dry and wet season from Navrongo, respectively. Navrongo is a region of high malaria transmission…

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16 May 2023 1306 Genetic diversity of Malaria parasites in Nigeria

Partner study description This proposal has been developed in response to recently published pilot data showing mutations in genes associated with resistance to artemisinins. The overall objective is to characterise genomic variation inPlasmodium…

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Publications

User guide

3,488 samples

from

23 countries

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Investigators involved in the P. falciparum Community Project include:

Documents

Funding support

Updates

6 Mar 2023

Partner data release (v7.0)

Plasmodium falciparum Community Project data, version 7.0 is now available. This release includes over 10.1 million SNPs based on an analysis of 20,864 samples from 54 partner studies in 33 countries. Details of the release are included in MalariaGEN et al, Wellcome Open Research 2023, 8:22 https://wellcomeopenresearch.org/articles/8-22