1044 Genomics of Plasmodium clearance and recrudescence rates in Cambodia

Partner study description

In field based studies, Rick Fairhurst and colleagues are investigating the genetic determinants of parasite clearance and recrudescence rates following treatment with artemisinin combination therapies (ACTs), and parasite infectivity to multiple Anopheles mosquito vectors in three Cambodian provinces, where artemisinin resistance is entrenched (Pursat), emerging (Preah Vihear), or uncommon (Ratanakiri). The overall goal of these studies is to identify genetic markers of antimalarial drug resistance, use them in real time to define frontline treatments at the provincial level, and eliminate multidrug-resistant malaria in the Greater Mekong Subregion. In related laboratory-based studies, these researchers aim to elucidate the molecular mechanisms of artemisinin and partner-drug resistance, to develop point-of care diagnostics to identify drug-resistant parasites, and discover new compounds to treat drug-resistant malaria episodes.

Key People

Chanaki Amaratunga
NIH National Institute of Allergy and Infectious Diseases (NIAID), USA
Dr Pharath Lim
NIH National Institute of Allergy and Infectious Diseases (NIAID), USA