1145 Genotype-phenotype study of erythrocyte invasion in Peruvian P. falciparum isolates

Projects:

Locations: Peru (PE)

Partner study description

Dionicia Gamboa, Joseph Vinetz and colleagues are analysing Peruvian P. falciparum host-parasite interactions during invasion of the parasite into the human red blood cell. Samples for this study were collected as part of a study of erythrocyte invasion phenotypes by the Universidad Peruana Cayetano Heredia, New York Blood Center and the University of California San Diego. The team will use whole genome sequencing on these phenotyped strains as part of broader genotype-phenotype studies of invasion both locally and globally. Samples from Peru that were collected as part of a study of erythrocyte invasion phenotypes by Universidad Peruana Cayetano Heredia, New York Blood Center and University of California San Diego. Plasmodium falciparum parasites were collected and tested for invasion phenotypes, as described in PMID 23118907. Strains were later retested for invasion and prepared for genome sequencing at the Sanger Institute. This project is led by Dr. Dionicia Gamboa and Dr. Joe Vinetz, with sequencing carried out in collaboration with Dr. Julian Rayner. Lead investigators are interested in analysing host-parasite interactions during invasion, as well as broader studies in genomic variation within Peru as part of the Peruvian/Brazilian Center of Excellence in Malaria Research (Amazonia ICEMR). Anyone interested in analysing these samples should contact Drs. Vinetz and Gamboa.

Key People

Dionicia Gamboa
Associated professor and Principal Investigator
Laboratorio ICEMR-Amazonia, Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
Joseph Vinetz
Professor of Medicine
Yale School of Medicine, New Haven, CT, USA
Laboratorio ICEMR-Amazonia, Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
Dr Julian C Rayner
Senior Group Leader, Malaria Programme
Wellcome Sanger Institute, UK
Director, Courses, Conferences and Public Engagement Programme
Wellcome Genome Campus, UK