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1138 Parenteral artesunate compared to quinine as a cause of late post-treatment anaemia in African children with hyperparasitaemic Plasmodium falciparum malaria (DHART)

Location: Congo (Democratic Republic of the Congo) (CD).

Parasite

Partner study description

Caterina Fanello and colleagues investigated the incidence of late onset anaemia in children with uncomplicated hyperparasitemic Plasmodium falciparum malaria treated with intravenous (IV) artesunate or IV quinine. Two blood samples were taken from patients in the Democratic Republic of Congo. The first to examine the parasite DNA to establish information on the frequency of the major alleles associated to drug resistance in the area and the other to analyse the human DNA for the presence of Sickle Cell Disease, thalassemia, G6PD deficiency and other hemoglobinopathies or enzyme deficiencies that might have affected the primary outcome of the clinical trial.