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1145 Genotype-phenotype study of erythrocyte invasion in Peruvian Plasmodium falciparum isolates

Location: Peru (PE).

Parasite

Partner study description

Dionicia Gamboa, Joseph Vinetz and colleagues are analysing Peruvian Plasmodium falciparum host-parasite interactions during invasion of the parasite into the human red blood cell. Samples for this study were collected as part of a study of erythrocyte invasion phenotypes by the Universidad Peruana Cayetano Heredia, New York Blood Center and the University of California San Diego. The team will use whole genome sequencing on these phenotyped strains as part of broader genotype-phenotype studies of invasion both locally and globally. Samples from Peru that were collected as part of a study of erythrocyte invasion phenotypes by Universidad Peruana Cayetano Heredia, New York Blood Center and University of California San Diego. P. falciparum parasites were collected and tested for invasion phenotypes, as described in PMID 23118907. Strains were later retested for invasion and prepared for genome sequencing at the Sanger Institute. This project is led by Dr. Dionicia Gamboa and Dr. Joe Vinetz, with sequencing carried out in collaboration with Dr. Julian Rayner. Lead investigators are interested in analysing host-parasite interactions during invasion, as well as broader studies in genomic variation within Peru as part of the Peruvian/Brazilian Center of Excellence in Malaria Research (Amazonia ICEMR). Anyone interested in analysing these samples should contact Drs. Vinetz and Gamboa.