Pearson RD, Amato R, Auburn S, Miotto O, Almagro-Garcia J, Amaratunga C, Suon S, Mao S, Noviyanti R, Trimarsanto H, Marfurt J, Anstey NM, William T, Boni MF, Dolecek C, Tran HT, White NJ, Michon P, Siba P, Tavul L, Harrison G, Barry A, Mueller I, Ferreira MU, Karunaweera N, Randrianarivelojosia M, Gao Q, Hubbart C, Hart L, Jeffery B, Drury E, Mead D, Kekre M, Campino S, Manske M, Cornelius VJ, MacInnis B, Rockett KA, Miles AM, Rayner JC, Fairhurst RM, Nosten F, Price RN, Kwiatkowski DP

Nature Genetics 2016 48 959-964 DOI: 10.1038/ng.3599

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11 Dec 2008

A global network for investigating the genomic epidemiology of malaria

Malaria Genomic Epidemiology Network

Nature 2008 456(7223) 732-7 DOI: 10.1038/nature07632

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Latest publications

7 Jun 2021

Arterolane–piperaquine–mefloquine versus arterolane–piperaquine and artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial

Hamaluba M, van der Pluijm RW, Weya J, Njuguna P, Ngama M, Kalume P, Mwambingu G, Ngetsa C, Wambua J, Boga M, Mturi N, Lal AA, Khuroo A, Taylor WRJ, Gonçalves S, Miotto O, Dhorda M, Mutinda B, Mukaka M, Waithira N, Hoglund RM, Imwong M, Tarning J, Day NPJ, White NJ, Bejon P, Dondorp AM

The Lancet Infectious Diseases 2021 20 30929-4 DOI: 10.1016/S1473-3099(20)30929-4

4 Jun 2021

About the Plasmodium falciparum version 7 data

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25 May 2021

A. Genetic variation at the Cyp6m2 putative insecticide resistance locus in Anopheles gambiae and Anopheles coluzzii.

Wagah MG, Korlević P, Clarkson C, Miles A; Anopheles gambiae 1000 Genomes Consortium, Lawniczak MKN, Makunin A

Malaria Journal 2021 20 234 DOI: 10.1186/s12936-021-03757-4

31 Mar 2021

The protective effect of sickle cell haemoglobin against severe malaria depends on parasite genotype

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9 Mar 2021

Discovery of Ongoing Selective Sweeps within Anopheles Mosquito Populations Using Deep Learning.

Xue AT, Schrider DR, Kern AD; Ag1000g Consortium.

Mol Biol Evol 2021 38 1168-1183 DOI: 10.1093/molbev/msaa259

15 Feb 2021

Novel genotyping approaches to easily detect genomic admixture between the major Afrotropical malaria vector species, Anopheles coluzzii and An. gambiae

Caputo B, Pichler V, Bottà G, De Marco C, Hubbart C, Perugini E, Pinto J, Rockett KA, Miles A, Della Torre A.

Mol Ecol Resour. 2021 DOI: 10.1111/1755-0998.13359

8 Feb 2021

Ag3: The Anopheles gambiae 1000 Genomes Project phase 3 data resource

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21 Jan 2021

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus.

Grau-Bové X, Lucas E, Pipini D, Rippon E, van 't Hof AE, Constant E, Dadzie S, Egyir-Yawson A, Essandoh J, Chabi J, Djogbénou L, Harding NJ, Miles A, Kwiatkowski D, Donnelly MJ, Weetman D; Anopheles gambiae 1000 Genomes Consortium.

PLoS Genetics 2021 17 DOI: 10.1371/journal.pgen.1009253

1 Oct 2020

Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression

Grau-Bové X, Tomlinson S, O'Reilly AO, Harding NJ, Miles A, Kwiatkowski D, Donnelly MJ, Weetman D; Anopheles gambiae 1000 Genomes Consortium.

Mol Biol Evol 2020 1 37 DOI: 10.1093/molbev/msaa128

25 Jul 2020

Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination: about the data

Jacob CG, Thuy-Nhien N, Mayxay M, et al.

MedRxiv 2020 DOI: 10.1101/2020.07.23.20159624

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21 Jan 2019

Genomic analysis of Plasmodium vivax in southern Ethiopia reveals selective pressures in multiple parasite mechanisms.

Auburn S, Getachew S, Pearson RD, Amato R, Miotto O, Trimarsanto H, Zhu SJ, Rumaseb A, Marfurt J, Noviyanti R, Grigg MJ, Barber B, William T, Goncalves SM, Drury E, Sriprawat K, Anstey NM, Nosten F, Petros B, Aseffa A, McVean G, Kwiatkowski DP, Price RN.

The Journal of Infectious Diseases 2019 DOI: 10.1093/infdis/jiz016

17 Dec 2018

Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka

Dewasurendra RL, Jeffreys A, Gunawardena SA, Chandrasekharan NV, Rockett K, Kwiatkowski D, & Karunaweera ND

Malaria Journal 2018 17 473 DOI: 10.1186/s12936-018-2622-9

4 Dec 2018

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Zhu l, Tripathi J, Rocamora FM, Miotto O, Van der Pluijm R, Voss TS, Mok S, Kwiatkowski DP, Nosten F, Day NPJ, White NJ, Dondorp AM & Bozdech Z.

Nature Communications 2018 9 5158 DOI: 10.1038/s41467-018-07588-x

29 Nov 2018

A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways

Campino S, Marin-Menendez A, Kemp A, Cross N, Drought l, Otto TD, Benavente ED, Ravenhall M, Schwach F, Girling G, Manske M, Theron M, Gould K, Drury E, Clark TG, Kwiatkowski DP, Pance A & Rayner JC.

PLoS Pathogens 2018 4(11) DOI: https://doi.org/10.1371/journal.ppat.1007436

25 Oct 2018

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development

Duffy CW, Amambua-Ngwa A, Ahouidi AD, Diakite M, Awandare GA, Ba H, Tarr SJ, Murray l, Stewart lB, D'Alessandro U, Otto TD, Kwiatkowski DP & Conway DJ.

Scientific Reports 2018 8 15763 DOI: 10.1038/s41598-018-34078-3

23 Jul 2018

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLbeta Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

Tessema SK, Utama D, Chesnokov O, Hodder AN, Lin CS, Harrison GLA, Jespersen JS, Petersen B, Tavul L, Siba P, Kwiatkowski D, Lavstsen T, Hansen DS, Oleinikov AV, Mueller I & Barry AE.

Infection and Immunity 2018 86 e00485-17 DOI: 10.1128/IAI.00485-17

19 Jul 2018

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B, Sepulveda N, Clark TG, Band G, Clarke G, Rowlands K, Hubbart C, Jeffreys A, Kariuki S, Marsh K, Mackinnon M, Maitland K, Kwiatkowski DP, Rockett KA & Williams TN.

The Lancet Haematology 2018 5 DOI: 10.1016/S2352-3026(18)30107-8

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26 Jun 2018

Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia

Amambua-Ngwa A, Jeffries D, Amato R, Worwui A, Karim M, Ceesay S, Nyang H, Nwakanma D, Okebe J, Kwiatkowski D, Conway J & D'Alessandro U.

Scientific Reports 2018 8 9687 DOI: 10.1038/s41598-018-28017-5

17 May 2018

Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics

Auburn S, Benavente ED, Miotto O, Pearson RD, Amato R, Grigg MJ, Barber B, William T, Handayuni I, Marfurt J, Trimarsanto H, Noviyanti R, Sriprawat K, Nosten F, Campino S, Clark TG, Anstey NA, Kwiatkowski DP, Price RN

Nature Communications 2018 9 2585 DOI: 10.1038/s41467-018-04965-4

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25 Apr 2018

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia

Opi DH, Swann O, Macharia A, Uyoga S, Band G, Ndila CM, Harrison EM, Thera MA, Kone AK, Diallo DA, Doumbo OK, lyke KE, Plowe CV, Moulds JM, Shebbe M, Mturi N, Peshu N, Maitland K, Raza A, Kwiatkowski DP, Rockett KA, Williams TN & Rowe JA.

eLife 2018 7 DOI: 10.7554/eLife.31579

7 Nov 2017

Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon: cross-sectional study

Apinjoh TO, Mugri RN, Miotto O, Chi HF, Tata RB, Anchang-Kimbi JK, Fon EM, Tangoh DA, Nyingchu RV, Jacob C, Amato R, Djimde A, Kwiatkowski D, Achidi EA, Amambua-Ngwa A.

Infectious Diseases of Poverty 2017 6 136 DOI: 10.1186/s40249-017-0350-y

22 Aug 2017

Deconvolution of multiple infections in Plasmodium falciparum from high throughput sequencing data

Zhu SJ, Almagro-Garcia J, McVean G.

Bioinformatics 2017 DOI: 10.1093/bioinformatics/btx530

23 Jun 2017

Panoptes: web-based exploration of large scale genome variation data

Vauterin P, Jeffery B, Miles A, Amato R, Hart L, Wright I, Kwiatkowski D

Bioinformatics 2017 DOI: 10.1093/bioinformatics/btx410

7 Jun 2017

Evidence from a natural experiment that malaria parasitemia is pathogenic in retinopathy-negative cerebral malaria

Small DS, Taylor TE, Postels DG, Beare NA, Cheng J, MacCormick IJ, Seydel KB

eLife 2017 6 e2369 DOI: 10.7554/eLife.23699

25 May 2017

Malaria host candidate genes validated by association with current, recent and historic measures of transmission intensity

Sepúlveda N, Manjurano A, Campino SG, Lemnge M, Lusingu J, Olomi R, Rockett KA, Hubbart C, Jeffreys A, Rowlands K; MalariaGen consortium, Clark TG, Riley EM, Drakeley CJ

The Journal of Infectious Diseases 2017 DOI: 10.1093/infdis/jix250

19 May 2017

Resistance to malaria through structural variation of red blood cell invasion receptors

Leffler EM, Band G, Busby GBJ, Kivinen K, Le SQ, Clarke GM, Bojang KA, Conway DJ, Jallow M, Sisay-Joof F, Bougouma EC, Mangano VD, Modiano D, Sirima SB, Achidi E, Apinjoh TO, Marsh K, Ndila CM, Peshu N, Williams TN, Drakeley C, Manjurano A, Hugh Reyburn H, Eleanor Riley E, Kachala D, Molyneux M, Nyirongo V, Taylor T, Thornton N, Tilley L, Grimsley S, Drury E, Stalker J, Cornelius VJ, Hubbart C, Jeffreys AE, Rowlands K, Rockett KA, Spencer CCA, Kwiatkowski DP, Malaria Genomic Epidemiology Network

Science 2017 DOI: 10.1126/science.aam6393

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19 May 2017

Resistance to malaria through structural variation of red blood cell invasion receptors

Science 2017 DOI: 10.1126/science.aam6393

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15 Mar 2017

Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution

Duffy CW, Ba H, Assefa S, Ahouidi AD, Deh YB, Tandia A, Kirsebom FC, Kwiatkowski DP, Conway DJ

Molecular Ecology 2017 DOI: 10.1111/mec.14066

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26 Jan 2017

THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites

Chang HH, Worby CJ, Yeka A, Nankabirwa J, Kamya MR, Staedke SG, Dorsey G, Murphy M, Neafsey DE, Jeffreys AE, Hubbart C, Rockett KA, Amato R, Kwiatkowski DP, Buckee C, Greenhouse B

PLoS Computational Biology 2017 13(1) e1005348 DOI: 10.1371/journal.pcbi.1005348

25 Jan 2017

Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

Rutledge GG, Böhme U, Sanders M, Reid AJ, Cotton JA, Maiga-Ascofare O, Djimdé AA, Apinjoh TO, Amenga-Etego L, Manske M, Barnwell JW, Renaud F, Ollomo B, Prugnolle F, Anstey NM, Auburn S, Price RN, McCarthy JS, Kwiatkowski DP, Newbold C, Berriman M, Otto TD

Nature 2017 DOI: 10.1038/nature21038