Pearson RD, Amato R, Auburn S, Miotto O, Almagro-Garcia J, Amaratunga C, Suon S, Mao S, Noviyanti R, Trimarsanto H, Marfurt J, Anstey NM, William T, Boni MF, Dolecek C, Tran HT, White NJ, Michon P, Siba P, Tavul L, Harrison G, Barry A, Mueller I, Ferreira MU, Karunaweera N, Randrianarivelojosia M, Gao Q, Hubbart C, Hart L, Jeffery B, Drury E, Mead D, Kekre M, Campino S, Manske M, Cornelius VJ, MacInnis B, Rockett KA, Miles AM, Rayner JC, Fairhurst RM, Nosten F, Price RN, Kwiatkowski DP

Nature Genetics 2016 48 959-964 DOI: 10.1038/ng.3599

Learn more

11 Dec 2008

A global network for investigating the genomic epidemiology of malaria

Malaria Genomic Epidemiology Network

Nature 2008 456(7223) 732-7 DOI: 10.1038/nature07632

Learn more

Latest publications

19 Apr 2022

Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 Variants

Tessema SK, Nakajima R, Jasinskas A, Monk SL, Lekieffre L, Lin E, Kiniboro B, Proietti C, Siba P, Felgner PL, Doolan DL, Mueller I, Barry AE.

Cell Host & Microbe 2019 26(5) 579-590.e5 DOI: https://doi.org/10.1016/j.chom.2019.10.012

19 Apr 2022

Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens

Naung MT, Martin E, Munro J, Mehra S, Guy AJ, Laman M, Harrison GLA, Tavul L, Hetzel M, Kwiatkowski D, Mueller I, Bahlo M, Barry AE.

PLoS Computational Biology 2022 18(2) e1009801 DOI: https://doi.org/10.1371/journal.pcbi.1009801

19 Apr 2022

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

Miotto O, Sekihara M, Tachibana SI, Yamauchi M, Pearson RD, Amato R, Gonçalves S, Mehra S, Noviyanti R, Marfurt J, Auburn S, Price RN, Mueller I, Ikeda M, Mori T, Hirai M, Tavul L, Hetzel MW, Laman M, Barry AE, Ringwald P, Ohashi J, Hombhanje F, Kwiatkowski DP, Mita T.

PLoS Pathogens 2020 16(12) e1009133 DOI: https://doi.org/10.1371/journal.ppat.1009133

8 Apr 2022

Plasmodium malariae and Plasmodium ovale infections and their association with common red blood cell polymorphisms in a highly endemic area of Uganda

Subissi L, Kanoi BN, Balikagala B, Egwang TG, Oguike M, Verra F, Proietti C, Bousema T, Drakeley CJ, Sepúlveda N

Transactions of The Royal Society of Tropical Medicine and Hygiene 2019 113(7) 370-378 DOI: https://doi.org/10.1093/trstmh/trz015

8 Apr 2022

Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda

Proietti C, Verra F, Bretscher MT, Stone W, Kanoi BN, Balikagala B, Egwang TG, Corran P, Ronca R, Arcà B, Riley EM, Crisanti A, Drakeley C, Bousema T

Parasite Immunology 2013 35(5-6) 164-73 DOI: https://doi.org/10.1111/pim.12031

4 Apr 2022

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Zhu L, van der Pluijm RW, Kucharski M, Nayak S, Tripathi J, White NJ, Day NPJ, Faiz A, Phyo AP, Amaratunga C, Lek D, Ashley EA, Nosten F, Smithuis F, Ginsburg H, von Seidlein L, Lin K, Imwong M, Chotivanich K, Mayxay M, Dhorda M, Nguyen HC, Nguyen TNT, Miotto O, Newton PN, Jittamala P, Tripura R, Pukrittayakamee S, Peto TJ, Hien TT, Dondorp AM, Bozdech Z.

Communications Biology 2022 5 274 DOI: https://doi.org/10.1038/s42003-022-03215-0

4 Apr 2022

Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

Imwong M, Dhorda M, Myo Tun K, Thu AM, Phyo AP, Proux S, Suwannasin K, Kunasol C, Srisutham S, Duanguppama J, Vongpromek R, Promnarate C, Saejeng A, Khantikul N, Sugaram R, Thanapongpichat S, Sawangjaroen N, Sutawong K, Han KT, Htut Y, Linn K, Win AA, Hlaing TM, van der Pluijm RW, Mayxay M, Pongvongsa T, Phommasone K, Tripura R, Peto TJ, von Seidlein L, Nguon C, Lek D, Chan XHS, Rekol H, Leang R, Huch C, Kwiatkowski DP, Miotto O, Ashley EA, Kyaw MP, Pukrittayakamee S, Day NPJ, Dondorp AM, Smithuis FM, Nosten FH, White NJ.

The Lancet Infectious Diseases 2020 20(12) 1470-1480 DOI: https://doi.org/10.1016/S1473-3099(20)30228-0

9 Dec 2021

The protective effect of sickle cell haemoglobin against severe malaria depends on parasite genotype

Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy Nguyen, Sónia Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto Amato, Eleanor Drury, Giorgio Sirugo, Umberto d’Alessandro, Kalifa A. Bojang, Kevin Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor, David J. Conway, Thomas N. Williams, Kirk A. Rockett & Dominic P. Kwiatkowski

Malaria protection due to sickle haemoglobin depends on parasite genotype 2021 DOI: https://doi.org/10.1038/s41586-021-04288-3

Learn more

12 Nov 2021

Amin1: Anopheles minimus genome variation data resource

Learn more

10 Aug 2021

Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination: about the data

Jacob CG, Thuy-Nhien N, Mayxay M, et al.

eLife 2021 10:e62997 DOI: 10.7554/eLife.62997

Learn more

10 Aug 2021

Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination: about the data

Jacob CG, Thuy-Nhien N, Mayxay M, et al.

eLife 2021 10:e62997 DOI: 10.7554/eLife.62997

Learn more

7 Jun 2021

Arterolane–piperaquine–mefloquine versus arterolane–piperaquine and artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial

Hamaluba M, van der Pluijm RW, Weya J, Njuguna P, Ngama M, Kalume P, Mwambingu G, Ngetsa C, Wambua J, Boga M, Mturi N, Lal AA, Khuroo A, Taylor WRJ, Gonçalves S, Miotto O, Dhorda M, Mutinda B, Mukaka M, Waithira N, Hoglund RM, Imwong M, Tarning J, Day NPJ, White NJ, Bejon P, Dondorp AM

The Lancet Infectious Diseases 2021 20 30929-4 DOI: 10.1016/S1473-3099(20)30929-4

4 Jun 2021

About the Plasmodium falciparum version 7 data

Learn more

25 May 2021

A. Genetic variation at the Cyp6m2 putative insecticide resistance locus in Anopheles gambiae and Anopheles coluzzii.

Wagah MG, Korlević P, Clarkson C, Miles A; Anopheles gambiae 1000 Genomes Consortium, Lawniczak MKN, Makunin A

Malaria Journal 2021 20 234 DOI: 10.1186/s12936-021-03757-4

31 Mar 2021

Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia

Abera D, Kibet CK, Degefa T, Amenga-Etego L, Bargul JL, Golassa L.

Malaria Journal 2021 20 129 DOI: https://doi.org/10.1186/s12936-021-03660-y

31 Mar 2021

Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia

Abera D, Kibet CK, Degefa T, Amenga-Etego L, Bargul JL, Golassa L.

Malaria Journal 2021 20 129 DOI: https://doi.org/10.1186/s12936-021-03660-y

9 Mar 2021

Discovery of Ongoing Selective Sweeps within Anopheles Mosquito Populations Using Deep Learning.

Xue AT, Schrider DR, Kern AD; Ag1000g Consortium.

Mol Biol Evol 2021 38 1168-1183 DOI: 10.1093/molbev/msaa259

15 Feb 2021

Novel genotyping approaches to easily detect genomic admixture between the major Afrotropical malaria vector species, Anopheles coluzzii and An. gambiae

Caputo B, Pichler V, Bottà G, De Marco C, Hubbart C, Perugini E, Pinto J, Rockett KA, Miles A, Della Torre A.

Mol Ecol Resour. 2021 DOI: 10.1111/1755-0998.13359

8 Feb 2021

Ag3: The Anopheles gambiae 1000 Genomes Project phase 3 data resource

Learn more

21 Jan 2021

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus.

Grau-Bové X, Lucas E, Pipini D, Rippon E, van 't Hof AE, Constant E, Dadzie S, Egyir-Yawson A, Essandoh J, Chabi J, Djogbénou L, Harding NJ, Miles A, Kwiatkowski D, Donnelly MJ, Weetman D; Anopheles gambiae 1000 Genomes Consortium.

PLoS Genetics 2021 17 DOI: 10.1371/journal.pgen.1009253

1 Oct 2020

Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression

Grau-Bové X, Tomlinson S, O'Reilly AO, Harding NJ, Miles A, Kwiatkowski D, Donnelly MJ, Weetman D; Anopheles gambiae 1000 Genomes Consortium.

Mol Biol Evol 2020 1 37 DOI: 10.1093/molbev/msaa128

21 Jan 2019

Genomic analysis of Plasmodium vivax in southern Ethiopia reveals selective pressures in multiple parasite mechanisms.

Auburn S, Getachew S, Pearson RD, Amato R, Miotto O, Trimarsanto H, Zhu SJ, Rumaseb A, Marfurt J, Noviyanti R, Grigg MJ, Barber B, William T, Goncalves SM, Drury E, Sriprawat K, Anstey NM, Nosten F, Petros B, Aseffa A, McVean G, Kwiatkowski DP, Price RN.

The Journal of Infectious Diseases 2019 220 1738-1749 DOI: 10.1093/infdis/jiz016

17 Dec 2018

Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka

Dewasurendra RL, Jeffreys A, Gunawardena SA, Chandrasekharan NV, Rockett K, Kwiatkowski D, & Karunaweera ND

Malaria Journal 2018 17 473 DOI: 10.1186/s12936-018-2622-9

4 Dec 2018

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Zhu l, Tripathi J, Rocamora FM, Miotto O, Van der Pluijm R, Voss TS, Mok S, Kwiatkowski DP, Nosten F, Day NPJ, White NJ, Dondorp AM & Bozdech Z.

Nature Communications 2018 9 5158 DOI: 10.1038/s41467-018-07588-x

29 Nov 2018

A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways

Campino S, Marin-Menendez A, Kemp A, Cross N, Drought l, Otto TD, Benavente ED, Ravenhall M, Schwach F, Girling G, Manske M, Theron M, Gould K, Drury E, Clark TG, Kwiatkowski DP, Pance A & Rayner JC.

PLoS Pathogens 2018 4(11) DOI: https://doi.org/10.1371/journal.ppat.1007436

25 Oct 2018

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development

Duffy CW, Amambua-Ngwa A, Ahouidi AD, Diakite M, Awandare GA, Ba H, Tarr SJ, Murray l, Stewart lB, D'Alessandro U, Otto TD, Kwiatkowski DP & Conway DJ.

Scientific Reports 2018 8 15763 DOI: 10.1038/s41598-018-34078-3

23 Jul 2018

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLbeta Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

Tessema SK, Utama D, Chesnokov O, Hodder AN, Lin CS, Harrison GLA, Jespersen JS, Petersen B, Tavul L, Siba P, Kwiatkowski D, Lavstsen T, Hansen DS, Oleinikov AV, Mueller I & Barry AE.

Infection and Immunity 2018 86 e00485-17 DOI: 10.1128/IAI.00485-17

19 Jul 2018

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B, Sepulveda N, Clark TG, Band G, Clarke G, Rowlands K, Hubbart C, Jeffreys A, Kariuki S, Marsh K, Mackinnon M, Maitland K, Kwiatkowski DP, Rockett KA & Williams TN.

The Lancet Haematology 2018 5 DOI: 10.1016/S2352-3026(18)30107-8

Learn more

26 Jun 2018

Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia

Amambua-Ngwa A, Jeffries D, Amato R, Worwui A, Karim M, Ceesay S, Nyang H, Nwakanma D, Okebe J, Kwiatkowski D, Conway D & D'Alessandro U.

Scientific Reports 2018 8 9687 DOI: 10.1038/s41598-018-28017-5

17 May 2018

Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics

Auburn S, Benavente ED, Miotto O, Pearson RD, Amato R, Grigg MJ, Barber B, William T, Handayuni I, Marfurt J, Trimarsanto H, Noviyanti R, Sriprawat K, Nosten F, Campino S, Clark TG, Anstey NA, Kwiatkowski DP, Price RN

Nature Communications 2018 9 2585 DOI: 10.1038/s41467-018-04965-4

Learn more