Publications

Featured publications

28 Sep 2020

Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii

The Anopheles gambiae 1000 Genomes Consortium
Genome Research 2020 30 1533-1546 DOI: 10.1101/gr.262790.120
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16 Dec 2019

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

Nature Communications 2019 10 5732 DOI: 10.1038/s41467-019-13480-z
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21 Jan 2019

Genomic analysis of Plasmodium vivax in southern Ethiopia reveals selective pressures in multiple parasite mechanisms.

Auburn S, Getachew S, Pearson RD, Amato R, Miotto O, Trimarsanto H, Zhu SJ, Rumaseb A, Marfurt J, Noviyanti R, Grigg MJ, Barber B, William T, Goncalves SM, Drury E, Sriprawat K, Anstey NM, Nosten F, Petros B, Aseffa A, McVean G, Kwiatkowski DP, Price RN.
The Journal of Infectious Diseases 2019 DOI: 10.1093/infdis/jiz016
17 Dec 2018

Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka

Dewasurendra RL, Jeffreys A, Gunawardena SA, Chandrasekharan NV, Rockett K, Kwiatkowski D, & Karunaweera ND
Malaria Journal 2018 17 473 DOI: 10.1186/s12936-018-2622-9
4 Dec 2018

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Zhu l, Tripathi J, Rocamora FM, Miotto O, Van der Pluijm R, Voss TS, Mok S, Kwiatkowski DP, Nosten F, Day NPJ, White NJ, Dondorp AM & Bozdech Z.
Nature Communications 2018 9 5158 DOI: 10.1038/s41467-018-07588-x
29 Nov 2018

A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways

Campino S, Marin-Menendez A, Kemp A, Cross N, Drought l, Otto TD, Benavente ED, Ravenhall M, Schwach F, Girling G, Manske M, Theron M, Gould K, Drury E, Clark TG, Kwiatkowski DP, Pance A & Rayner JC.
PLoS Pathogens 2018 4(11) DOI: https://doi.org/10.1371/journal.ppat.1007436
25 Oct 2018

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development

Duffy CW, Amambua-Ngwa A, Ahouidi AD, Diakite M, Awandare GA, Ba H, Tarr SJ, Murray l, Stewart lB, D'Alessandro U, Otto TD, Kwiatkowski DP & Conway DJ.
Scientific Reports 2018 8 15763 DOI: 10.1038/s41598-018-34078-3
23 Jul 2018

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLbeta Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

Tessema SK, Utama D, Chesnokov O, Hodder AN, Lin CS, Harrison GLA, Jespersen JS, Petersen B, Tavul L, Siba P, Kwiatkowski D, Lavstsen T, Hansen DS, Oleinikov AV, Mueller I & Barry AE.
Infection and Immunity 2018 86 e00485-17 DOI: 10.1128/IAI.00485-17
19 Jul 2018

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B, Sepulveda N, Clark TG, Band G, Clarke G, Rowlands K, Hubbart C, Jeffreys A, Kariuki S, Marsh K, Mackinnon M, Maitland K, Kwiatkowski DP, Rockett KA & Williams TN.
The Lancet Haematology 2018 5 DOI: 10.1016/S2352-3026(18)30107-8
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26 Jun 2018

Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia

Amambua-Ngwa A, Jeffries D, Amato R, Worwui A, Karim M, Ceesay S, Nyang H, Nwakanma D, Okebe J, Kwiatkowski D, Conway J & D'Alessandro U.
Scientific Reports 2018 8 9687 DOI: 10.1038/s41598-018-28017-5
17 May 2018

Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics

Auburn S, Benavente ED, Miotto O, Pearson RD, Amato R, Grigg MJ, Barber B, William T, Handayuni I, Marfurt J, Trimarsanto H, Noviyanti R, Sriprawat K, Nosten F, Campino S, Clark TG, Anstey NA, Kwiatkowski DP, Price RN
Nature Communications 2018 9 2585 DOI: 10.1038/s41467-018-04965-4
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25 Apr 2018

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia

Opi DH, Swann O, Macharia A, Uyoga S, Band G, Ndila CM, Harrison EM, Thera MA, Kone AK, Diallo DA, Doumbo OK, lyke KE, Plowe CV, Moulds JM, Shebbe M, Mturi N, Peshu N, Maitland K, Raza A, Kwiatkowski DP, Rockett KA, Williams TN & Rowe JA.
eLife 2018 7 DOI: 10.7554/eLife.31579
1 Feb 2018

Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study

Amato R, Pearson RD, Almagro-Garcia J, Amaratunga C, PhD, Lim P, Suon S, Sreng S, Drury E, Stalker J, Miotto O, Fairhurst R, Kwiatkowski DP
The Lancet Infectious Diseases 2018 18 337-345 DOI: 10.1016/S1473-3099(18)30068-9
29 Nov 2017

Genetic diversity of the African malaria vector Anopheles gambiae

The Anopheles gambiae 1000 Genomes Consortium
Nature 2017 DOI: 10.1038/nature24995
23 Jun 2017

Panoptes: web-based exploration of large scale genome variation data

Vauterin P, Jeffery B, Miles A, Amato R, Hart L, Wright I, Kwiatkowski D
Bioinformatics 2017 DOI: 10.1093/bioinformatics/btx410
19 May 2017

Resistance to malaria through structural variation of red blood cell invasion receptors

Leffler EM, Band G, Busby GBJ, Kivinen K, Le SQ, Clarke GM, Bojang KA, Conway DJ, Jallow M, Sisay-Joof F, Bougouma EC, Mangano VD, Modiano D, Sirima SB, Achidi E, Apinjoh TO, Marsh K, Ndila CM, Peshu N, Williams TN, Drakeley C, Manjurano A, Hugh Reyburn H, Eleanor Riley E, Kachala D, Molyneux M, Nyirongo V, Taylor T, Thornton N, Tilley L, Grimsley S, Drury E, Stalker J, Cornelius VJ, Hubbart C, Jeffreys AE, Rowlands K, Rockett KA, Spencer CCA, Kwiatkowski DP, Malaria Genomic Epidemiology Network
Science 2017 DOI: 10.1126/science.aam6393
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15 Mar 2017

Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution

Duffy CW, Ba H, Assefa S, Ahouidi AD, Deh YB, Tandia A, Kirsebom FC, Kwiatkowski DP, Conway DJ
Molecular Ecology 2017 DOI: 10.1111/mec.14066
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9 Jan 2017

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

Clarke GM, Rockett K, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu OK, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Sepúlveda N, Clark TG, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Hoan Phu N, Ngoc Quyen N, Quang Thai C, Tinh Hien T, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TME, Michon P, Mueller I Molloy SF, Campino S, Kerasidou A, Cornelius VJ, Hart L, Shah SS, Band G, Spencer CCA, Agbenyega T, Achidi E, Doumbo OK, Farrar J, Marsh K, Taylor T, Kwiatkowski DP, MalariaGEN Consortium
eLife 2017 6 e15085 DOI: 10.7554/eLife.15085
20 Dec 2016

Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification

Oyola SO, Ariani CV, Hamilton W, Kekre M, Amenga-Etego L, Ghansah A, Rutledge GR, Redmond S, Manske M, Jyothi D, Jacob CG, Otto T, Rockett K, Newbold CI, Berriman M, Kwiatkowski P
Malaria Journal 2016 15 597 DOI: 10.1186/s12936-016-1641-7
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3 Nov 2016

Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study

Amato R, Lim P, Miotto O, Amaratunga C, Dek D, Pearson RD, Almagro-Garcia J, Neal AT, Sreng S, Suon S, Drury E, Jyothi D, Stalker J, Kwiatkowski DP, Fairhurst RM
The Lancet Infectious Diseases 2016 DOI: 10.1016/S1473-3099(16)30409-1
16 Aug 2016

Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum

Miles A, Iqbal Z, Vauterin P, Pearson R, Campino S, Theron M, Gould K, Mead D, Drury E, O'Brien J, Ruano Rubio V, MacInnis B, Mwangi J, Samarakoon U, Ranford-Cartwright L, Ferdig M, Hayton K, Su XZ, Wellems T, Rayner J, McVean G, Kwiatkowski D
Genome Research 2016 26 1288-1299 DOI: 10.1101/gr.203711.115.
27 Jun 2016

Genomic analysis of local variation and recent evolution in Plasmodium vivax

Pearson RD, Amato R, Auburn S, Miotto O, Almagro-Garcia J, Amaratunga C, Suon S, Mao S, Noviyanti R, Trimarsanto H, Marfurt J, Anstey NM, William T, Boni MF, Dolecek C, Tran HT, White NJ, Michon P, Siba P, Tavul L, Harrison G, Barry A, Mueller I, Ferreira MU, Karunaweera N, Randrianarivelojosia M, Gao Q, Hubbart C, Hart L, Jeffery B, Drury E, Mead D, Kekre M, Campino S, Manske M, Cornelius VJ, MacInnis B, Rockett KA, Miles AM, Rayner JC, Fairhurst RM, Nosten F, Price RN, Kwiatkowski DP
Nature Genetics 2016 48 959-964 DOI: 10.1038/ng.3599
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21 Jun 2016

Admixture into and within sub-Saharan Africa

Busby G, Band G, Le SQ, Jallow M, Bougama E, Mangano V, Amenga-Etego L, Emil A, Apinjoh T, Ndila C, Manjurano A, Nyirongo V, Doumbo O, Rockett K, Kwiatkowski D, Spencer C, The Malaria Genomic Epidemiology Network
eLife 2016 5:e15266 DOI: 10.7554/eLife.15266
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4 Mar 2016

Genomic epidemiology of artemisinin resistant malaria

MalariaGEN P. falciparum Community Project
eLife 2016 5 e08714 DOI: 10.7554/eLife.08714
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30 Sep 2015

A novel locus of resistance to severe malaria in a region of ancient balancing selection

Malaria Genomic Epidemiology Network
Nature 2015 526(7572) 253-257 DOI: 10.1038/nature15390
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28 Aug 2015

Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Shelton JM, Corran P, Risley P, Silva N, Hubbart C, Jeffreys A, Rowlands K, Craik R, Cornelius V, Hensmann M, Molloy S, Sepulveda N, Clark TG, Band G, Clarke GM, Spencer CC, Kerasidou A, Campino S, Auburn S, Tall A, Ly AB, Mercereau-Puijalon O, Sakuntabhai A, Djimdé A, Maiga B, Touré O, Doumbo OK, Dolo A, Troye-Blomberg M, Mangano VD, Verra F, Modiano D, Bougouma E, Sirima SB, Ibrahim M, Hussain A, Eid N, Elzein A, Mohammed H, Elhassan A, Elhassan I, Williams TN, Ndila C, Macharia A, Marsh K, Manjurano A, Reyburn H, Lemnge M, Ishengoma D, Carter R, Karunaweera N, Fernando D, Dewasurendra R, Drakeley CJ, Riley EM, Kwiatkowski DP, Rockett KA; MalariaGEN Consortium
Malaria Journal 2015 14 333 DOI: 10.1186/s12936-015-0833-x
19 Jan 2015

Genetic architecture of artemisinin-resistant Plasmodium falciparum

Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J, Amaratunga C, Lim P, Mead D, Oyola SO, Dhorda M, Imwong M, Woodrow C, Manske M, Stalker J, Drury E, Campino S, Amenga-Etego L, Thanh TN, Tran HT, Ringwald P, Bethell D, Nosten F, Phyo AP, Pukrittayakamee S, Chotivanich K, Chuor CM, Nguon C, Suon S, Sreng S, Newton PN, Mayxay M, Khanthavong M, Hongvanthong B, Htut Y, Han KT, Kyaw MP, Faiz MA, Fanello C, Onyamboko M, Mokuolu OA, Jacob CG, Takala-Harrison S, Plowe CV, Day NP, Dondorp AM, Spencer CC, McVean G, Fairhurst RM, White NJ, Kwiatkowski DP
Nature Genetics 2015 47(3) 226-34 DOI: 10.1038/ng.3189
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28 Sep 2014

Reappraisal of known malaria resistance loci in a large multi-centre study

Rockett KA, Clarke GM, Fitzpatrick K, Hubbart C, Jeffreys AE, Rowlands K, Craik R, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu O, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NT, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Green A, Molloy S, Johnson KJ, Kerasidou A, Cornelius V, Hart L, Vanderwal A, SanJoaquin M, Band G, Le SQ, Pirinen M, Sepúlveda N, Spencer CC, Clark TG, Agbenyega T, Achidi E, Doumbo O, Farrar J, Marsh K, Taylor T, Kwiatkowski DP for Malaria Genomic Epidemiology Network
Nature Genetics 2014 46(11) 1197-204 DOI: 10.1038/ng.3107
28 Apr 2013

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Duong S, Nguon C, Chuor CM, Saunders D, Se Y, Lon C, Fukuda MM, Amenga-Etego L, Hodgson AV, Asoala V, Imwong M, Takala-Harrison S, Nosten F, Su XZ, Ringwald P, Ariey F, Dolecek C, Hien TT, Boni MF, Thai CQ, Amambua-Ngwa A, Conway DJ, Djimdé AA, Doumbo OK, Zongo I, Ouedraogo JB, Alcock D, Drury E, Auburn S, Koch O, Sanders M, Hubbart C, Maslen G, Ruano-Rubio V, Jyothi D, Miles A, O'Brien J, Gamble C, Oyola SO, Rayner JC, Newbold CI, Berriman M, Spencer CC, McVean G, Day NP, White NJ, Bethell D, Dondorp AM, Plowe CV, Fairhurst RM, Kwiatkowski DP
Nature Genetics 2013 45(6) 648-55 DOI: 10.1038/ng.2624
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19 Jul 2012

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O'Brien J, Djimde A, Doumbo O, Zongo I, Ouedraogo JB, Michon P, Mueller I, Siba P, Nzila A, Borrmann S, Kiara SM, Marsh K, Jiang H, Su XZ, Amaratunga C, Fairhurst R, Socheat D, Nosten F, Imwong M, White NJ, Sanders M, Anastasi E, Alcock D, Drury E, Oyola S, Quail MA, Turner DJ, Ruano-Rubio V, Jyothi D, Amenga-Etego L, Hubbart C, Jeffreys A, Rowlands K, Sutherland C, Roper C, Mangano V, Modiano D, Tan JC, Ferdig MT, Amambua-Ngwa A, Conway DJ, Takala-Harrison S, Plowe CV, Rayner JC, Rockett KA, Clark TG, Newbold CI, Berriman M, MacInnis B, Kwiatkowski DP
Nature 2012 487(7407) 375-9 DOI: 10.1038/nature11174
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24 Nov 2009

Ethical data-release in genome-wide association studies in developing countries

Parker M, Bull SJ, de Vries J, Agbenyega T, Doumbo OK, Kwiatkowski DP
PLoS Medicine 2009 6(11) e1000143 DOI: 10.1371/journal.pmed.1000143
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24 May 2009

Genome-wide and fine-resolution association analysis of malaria in West Africa

Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, SanJoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP; Wellcome Trust Case Control Consortium; Malaria Genomic Epidemiology Network
Nature Genetics 2009 41(6) 657-65 DOI: 10.1038/ng.388
11 Dec 2008

A global network for investigating the genomic epidemiology of malaria

Malaria Genomic Epidemiology Network
Nature 2008 456(7223) 732-7 DOI: 10.1038/nature07632
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Latest publications

31 Mar 2021

The protective effect of sickle cell haemoglobin against severe malaria depends on parasite genotype

Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy Nguyen, Sonia M. Goncalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto Amato, Eleanor Drury, Giorgio Sirugo, Umberto D'Alessandro, Kalifa A. Bojang, Kevin Marsh, Norbert Peshu, David J. Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski
Preprint available on bioRxiv 2021
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24 Feb 2021

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

MalariaGEN, Ambroise Ahouidi, Mozam Ali, Jacob Almagro-Garcia, Alfred Amambua-Ngwa, Chanaki Amaratunga, Roberto Amato,Lucas Amenga-Etego, Ben Andagalu, Tim J. C. Anderson, Voahangy Andrianaranjaka, Tobias Apinjoh, Cristina Ariani, Elizabeth A. Ashley, Sarah Auburn, Gordon Awandare, Hampate Ba, Vito Baraka, Alyssa E. Barry1, Philip Bejon, Gwladys I. Bertin, Maciej F. Boni, Steffen Borrmann, Teun Bousema, Oralee Branch, Peter C. Bull, George B. J. Busby, Thanat Chookajorn, Kesinee Chotivanich, Antoine Claessens, David Conway, Alister Craig, Umberto D'Alessandro, Souleymane Dama, Nicholas Day, Brigitte Denis, Mahamadou Diakite, Abdoulaye Djimdé, Christiane Dolecek, Arjen Dondorp, Chris Drakeley, Eleanor Drury, Patrick Duffy, Diego F. Echeverry, Thomas G. Egwang, Berhanu Erko, Rick M. Fairhurst, Abdul Faiz, Caterina A. Fanello, Mark M. Fukuda, Dionicia Gamboa, Anita Ghansah, Lemu Golassa, Sonia Goncalves, William L. Hamilton, G. L. Abby Harrison, Lee Hart, Christa Henrichs, Tran Tinh Hien, Catherine A. Hill, Abraham Hodgson, Christina Hubbart, Mallika Imwong, Deus S. Ishengoma, Scott A. Jackson, Chris G. Jacob, Ben Jeffery, Anna E. Jeffreys, Kimberly J. Johnson, Dushyanth Jyothi, Claire Kamaliddin, Edwin Kamau, Mihir Kekre, Krzysztof Kluczynski, Theerarat Kochakarn, Abibatou Konaté, Dominic P. Kwiatkowski, Myat Phone Kyaw, Pharath Lim, Chanthap Lon, Kovana M. Loua, Oumou Maïga-Ascofaré, Cinzia Malangone, Magnus Manske, Jutta Marfurt, Kevin Marsh, Mayfong Mayxay, Alistair Miles, Olivo Miotto, Victor Mobegi, Olugbenga A. Mokuolu, Jacqui Montgomery, Ivo Mueller, Paul N. Newton, Thuy Nguyen, Thuy-Nhien Nguyen, Harald Noedl, Francois Nosten, Rintis Noviyanti, Alexis Nzila, Lynette I. Ochola-Oyier, Harold Ocholla, Abraham Oduro, Irene Omedo, Marie A. Onyamboko, Jean-Bosco Ouedraogo, Kolapo Oyebola, Richard D. Pearson, Norbert Peshu, Aung Pyae Phyo, Chris V. Plowe, Ric N. Price, Sasithon Pukrittayakamee, Milijaona Randrianarivelojosia, Julian C. Rayner, Pascal Ringwald, Kirk A. Rockett, Katherine Rowlands, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Victoria J. Simpson, Jim Stalker, Xin-zhuan Su, Colin Sutherland, Shannon Takala-Harrison, Livingstone Tavul, Vandana Thathy, Antoinette Tshefu, Federica Verra, Joseph Vinetz, Thomas E. Wellems, Jason Wendler, Nicholas J. White, Ian Wright, William Yavo, Htut Ye.
Wellcome Open Research 2021 DOI: https://doi.org/10.12688/wellcomeopenres.16168.1
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25 Jul 2020

Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination: about the data

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25 Sep 2019

Plasmodium falciparum Community Project: about the version 6 data

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7 Nov 2017

Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon: cross-sectional study

Apinjoh TO, Mugri RN, Miotto O, Chi HF, Tata RB, Anchang-Kimbi JK, Fon EM, Tangoh DA, Nyingchu RV, Jacob C, Amato R, Djimde A, Kwiatkowski D, Achidi EA, Amambua-Ngwa A.
Infectious Diseases of Poverty 2017 6 136 DOI: 10.1186/s40249-017-0350-y
22 Aug 2017

Deconvolution of multiple infections in Plasmodium falciparum from high throughput sequencing data

Zhu SJ, Almagro-Garcia J, McVean G.
Bioinformatics 2017 DOI: 10.1093/bioinformatics/btx530
7 Jun 2017

Evidence from a natural experiment that malaria parasitemia is pathogenic in retinopathy-negative cerebral malaria

Small DS, Taylor TE, Postels DG, Beare NA, Cheng J, MacCormick IJ, Seydel KB
eLife 2017 6 e2369 DOI: 10.7554/eLife.23699
25 May 2017

Malaria host candidate genes validated by association with current, recent and historic measures of transmission intensity

Sepúlveda N, Manjurano A, Campino SG, Lemnge M, Lusingu J, Olomi R, Rockett KA, Hubbart C, Jeffreys A, Rowlands K; MalariaGen consortium, Clark TG, Riley EM, Drakeley CJ
The Journal of Infectious Diseases 2017 DOI: 10.1093/infdis/jix250
26 Jan 2017

THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites

Chang HH, Worby CJ, Yeka A, Nankabirwa J, Kamya MR, Staedke SG, Dorsey G, Murphy M, Neafsey DE, Jeffreys AE, Hubbart C, Rockett KA, Amato R, Kwiatkowski DP, Buckee C, Greenhouse B
PLoS Computational Biology 2017 13(1) e1005348 DOI: 10.1371/journal.pcbi.1005348
25 Jan 2017

Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

Rutledge GG, Böhme U, Sanders M, Reid AJ, Cotton JA, Maiga-Ascofare O, Djimdé AA, Apinjoh TO, Amenga-Etego L, Manske M, Barnwell JW, Renaud F, Ollomo B, Prugnolle F, Anstey NM, Auburn S, Price RN, McCarthy JS, Kwiatkowski DP, Newbold C, Berriman M, Otto TD
Nature 2017 DOI: 10.1038/nature21038
24 Jan 2017

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants

Claessens A, Affara M, Assefa SA, Kwiatkowski DP, Conway DJ
Scientific Reports 2017 7 41303 DOI: 10.1038/srep41303
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19 Dec 2016

Extreme mutation bias and high AT content in Plasmodium falciparum

Hamilton WL, Claessens A, Otto TD, Kekre M, Fairhurst RM, Rayner JC, Kwiatkowski D
Nucleic Acids Research 2016 pii gkw1259 DOI: 10.1093/nar/gkw1259
14 Oct 2016

Independent origin and global distribution of distinct Plasmodium vivax Duffy Binding Protein gene duplications

Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, Rayner JC
PLoS Neglected Tropical Diseases 2016 10(10) e0005091 DOI: 10.1371/journal.pntd.0005091
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8 Mar 2016

The ethics of sustainable genomic research in Africa

Parker M, Kwiatkowski DP
Genome Biology 2016 17 44 DOI: 10.1186/s13059-016-0914-3
16 Jul 2015

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity

Duffy CW, Assefa SA, Abugri J, Amoako N, Owusu-Agyei S, Anyorigiya T, MacInnis B, Kwiatkowski DP, Conway DJ, Awandare GA
BMC Genomics 2015 16 527 DOI: 10.1186/s12864-015-1746-3
16 Jun 2015

Understandings of genomic research in developing countries: a qualitative study of the views of MalariaGEN participants in Mali

Traore K, Bull S, Niare A, Konate S, Thera MA, Kwiatkowski D, Parker M, Doumbo OK
BMC Medical Ethics 2015 16 42 DOI: 10.1186/s12910-015-0035-7
15 Apr 2015

K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa

Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D, Johnson K, Mumba D, Kekre M, Yavo W, Mead D, Bouyou-Akotet M, Apinjoh T, Golassa L, Randrianarivelojosia M, Andagalu B, Maiga-Ascofare O, Amambua-Ngwa A, Tindana P, Ghansah A, MacInnis B, Kwiatkowski D, Djimde AA
Journal of Infectious Diseases 2015 211(8) 1352-5 DOI: 10.1093/infdis/jiu608
24 Mar 2015

USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania

Manjurano A, Sepúlveda N, Nadjm B, Mtove G, Wangai H, Maxwell C, Olomi R, Reyburn H, Drakeley CJ, Riley EM, Clark TG; in Collaboration With MalariaGEN
Journal of Infectious Diseases 2015 212(7) 1129-39 DOI: 10.1093/infdis/jiv192
23 Feb 2015

Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia

Mangano VD, Kabore Y, Bougouma EC, Verra F, Sepulveda N, Bisseye C, Santolamazza F, Avellino P, Tiono AB, Diarra A, Nebie I, Rockett KA, Sirima SB, Modiano D; MalariaGEN Consortium
Journal of Infectious Diseases 2015 212(4) 626-34 DOI: 10.1093/infdis/jiv098
22 Feb 2015

G6PD gene variants and its association with malaria in a Sri Lankan population

Dewasurendra RL, Rockett KA, Fernando SD, Carter R, Kwiatkowski DP, Karunaweera ND; MalariaGEN Consortium
Malaria Journal 2015 14 93 DOI: 10.1186/s12936-015-0603-9
11 Feb 2015

African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania

Manjurano A, Sepulveda N, Nadjm B, Mtove G, Wangai H, Maxwell C, Olomi R, Reyburn H, Riley EM, Drakeley CJ, Clark TG; MalariaGEN Consortium
PloS Genetics 2015 11(2) e1004960 DOI: 10.1371/journal.pgen.1004960
15 Dec 2014

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates

Ocholla H, Preston MD, Mipando M, Jensen AT, Campino S, MacInnis B, Alcock D, Terlouw A, Zongo I, Oudraogo JB, Djimde AA, Assefa S, Doumbo OK, Borrmann S, Nzila A, Marsh K, Fairhurst RM, Nosten F, Anderson TJ, Kwiatkowski DP, Craig A, Clark TG, Montgomery J
Journal of Infectious Diseases 2014 210(12) 1991-2000 DOI: 10.1093/infdis/jiu349
13 Aug 2014

Knowing who to trust: exploring the role of 'ethical metadata' in mediating risk of harm in collaborative genomics research in Africa

de Vries J, Williams TN, Bojang K, Kwiatkowski DP, Fitzpatrick R, Parker M
BMC Medical Ethics 2014 15 62 DOI: 10.1186/1472-6939-15-62
11 Jul 2014

Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali

Maiga B, Dolo A, Campino S, Sepulveda N, Corran P, Rockett KA, Troye-Blomberg M, Doumbo OK, Clark TG
Malaria Journal 2014 13 270 DOI: 10.1186/1475-2875-13-270
25 Jun 2014

Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation

Clarkson CS, Weetman D, Essandoh J, Yawson AE, Maslen G, Manske M, Field SG, Webster M, Antão T, MacInnis B, Kwiatkowski D, Donnelly MJ
Nature Communications 2014 5 4248 DOI: 10.1038/ncomms5248
16 Jun 2014

Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study

Apinjoh TO, Anchang-Kimbi JK, Njua-Yafi C, Ngwai AN, Mugri RN, Clark TG, Rockett KA, Kwiatkowski DP, Achidi EA; MalariaGEN Consortium
Malaria Journal 2014 13 236 DOI: 10.1186/1475-2875-13-236
27 Nov 2013

Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon

Apinjoh TO, Anchang-Kimbi JK, Njua-Yafi C, Mugri RN, Ngwai AN, Rockett KA, Mbunwe E, Besingi RN, Clark TG, Kwiatkowski DP, Achidi EA; MalariaGEN Consortium
PLoS One 2013 8(11) e81071 DOI: 10.1371/journal.pone.0081071
2 Oct 2013

Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali

Maiga B, Dolo A, Touré O, Dara V, Tapily A, Campino S, Sepulveda N, Risley P, Silva N, Corran P, Rockett KA, Kwiatkowski D; MalariaGEN Consortium, Clark TG, Troye-Blomberg M, Doumbo OK
PLoS One 2013 8(10) e75675 DOI: 10.1371/journal.pone.0075675
23 May 2013

Imputation-based meta-analysis of severe malaria in three African populations

Band G, Le QS, Jostins L, Pirinen M, Kivinen K, Jallow M, Sisay-Joof F, Bojang K, Pinder M, Sirugo G, Conway DJ, Nyirongo V, Kachala D, Molyneux M, Taylor T, Ndila C, Peshu N, Marsh K, Williams TN, Alcock D, Andrews R, Edkins S, Gray E, Hubbart C, Jeffreys A, Rowlands K, Schuldt K, Clark TG, Small KS, Teo YY, Kwiatkowski DP, Rockett KA, Barrett JC, Spencer CC; Malaria Genomic Epidemiology Network
PloS Genetics 2013 9(5) e1003509 DOI: 10.1371/journal.pgen.1003509
1 Nov 2012

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites

Amambua-Ngwa A, Tetteh KK, Manske M, Gomez-Escobar N, Stewart LB, Deerhake ME, Cheeseman IH, Newbold CI, Holder AA, Knuepfer E, Janha O, Jallow M, Campino S, Macinnis B, Kwiatkowski DP, Conway DJ
PLoS Genetics 2012 8(11) e1002992 DOI: 10.1371/journal.pgen.1002992