Publications
Featured publications
28 Sep 2020
Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii
Genome Research 2020 30 1533-1546 DOI: 10.1101/gr.262790.12016 Dec 2019
Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania
Nature Communications 2019 10 5732 DOI: 10.1038/s41467-019-13480-z21 Jan 2019
Genomic analysis of Plasmodium vivax in southern Ethiopia reveals selective pressures in multiple parasite mechanisms.
The Journal of Infectious Diseases 2019 DOI: 10.1093/infdis/jiz01617 Dec 2018
Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka
Malaria Journal 2018 17 473 DOI: 10.1186/s12936-018-2622-94 Dec 2018
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
Nature Communications 2018 9 5158 DOI: 10.1038/s41467-018-07588-x29 Nov 2018
A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways
PLoS Pathogens 2018 4(11) DOI: https://doi.org/10.1371/journal.ppat.100743625 Oct 2018
Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development
Scientific Reports 2018 8 15763 DOI: 10.1038/s41598-018-34078-323 Jul 2018
Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLbeta Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea
Infection and Immunity 2018 86 e00485-17 DOI: 10.1128/IAI.00485-1719 Jul 2018
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
The Lancet Haematology 2018 5 DOI: 10.1016/S2352-3026(18)30107-826 Jun 2018
Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia
Scientific Reports 2018 8 9687 DOI: 10.1038/s41598-018-28017-517 May 2018
Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics
Nature Communications 2018 9 2585 DOI: 10.1038/s41467-018-04965-425 Apr 2018
Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia
eLife 2018 7 DOI: 10.7554/eLife.315791 Feb 2018
Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study
The Lancet Infectious Diseases 2018 18 337-345 DOI: 10.1016/S1473-3099(18)30068-929 Nov 2017
Genetic diversity of the African malaria vector Anopheles gambiae
Nature 2017 DOI: 10.1038/nature2499523 Jun 2017
Panoptes: web-based exploration of large scale genome variation data
Bioinformatics 2017 DOI: 10.1093/bioinformatics/btx41019 May 2017
Resistance to malaria through structural variation of red blood cell invasion receptors
Science 2017 DOI: 10.1126/science.aam639315 Mar 2017
Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution
Molecular Ecology 2017 DOI: 10.1111/mec.140669 Jan 2017
Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia
eLife 2017 6 e15085 DOI: 10.7554/eLife.1508520 Dec 2016
Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification
Malaria Journal 2016 15 597 DOI: 10.1186/s12936-016-1641-73 Nov 2016
Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study
The Lancet Infectious Diseases 2016 DOI: 10.1016/S1473-3099(16)30409-116 Aug 2016
Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum
Genome Research 2016 26 1288-1299 DOI: 10.1101/gr.203711.115.27 Jun 2016
Genomic analysis of local variation and recent evolution in Plasmodium vivax
Nature Genetics 2016 48 959-964 DOI: 10.1038/ng.359921 Jun 2016
Admixture into and within sub-Saharan Africa
eLife 2016 5:e15266 DOI: 10.7554/eLife.152664 Mar 2016
Genomic epidemiology of artemisinin resistant malaria
eLife 2016 5 e08714 DOI: 10.7554/eLife.0871430 Sep 2015
A novel locus of resistance to severe malaria in a region of ancient balancing selection
Nature 2015 526(7572) 253-257 DOI: 10.1038/nature1539028 Aug 2015
Genetic determinants of anti-malarial acquired immunity in a large multi-centre study
Malaria Journal 2015 14 333 DOI: 10.1186/s12936-015-0833-x19 Jan 2015
Genetic architecture of artemisinin-resistant Plasmodium falciparum
Nature Genetics 2015 47(3) 226-34 DOI: 10.1038/ng.318928 Sep 2014
Reappraisal of known malaria resistance loci in a large multi-centre study
Nature Genetics 2014 46(11) 1197-204 DOI: 10.1038/ng.310728 Apr 2013
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Nature Genetics 2013 45(6) 648-55 DOI: 10.1038/ng.262419 Jul 2012
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
Nature 2012 487(7407) 375-9 DOI: 10.1038/nature1117424 Nov 2009
Ethical data-release in genome-wide association studies in developing countries
PLoS Medicine 2009 6(11) e1000143 DOI: 10.1371/journal.pmed.100014324 May 2009
Genome-wide and fine-resolution association analysis of malaria in West Africa
Nature Genetics 2009 41(6) 657-65 DOI: 10.1038/ng.38811 Dec 2008
A global network for investigating the genomic epidemiology of malaria
Nature 2008 456(7223) 732-7 DOI: 10.1038/nature07632Latest publications
24 Feb 2021
An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples
Wellcome Open Research 2021 DOI: https://doi.org/10.12688/wellcomeopenres.16168.125 Jul 2020
Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination: about the data
7 Nov 2017
Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon: cross-sectional study
Infectious Diseases of Poverty 2017 6 136 DOI: 10.1186/s40249-017-0350-y22 Aug 2017
Deconvolution of multiple infections in Plasmodium falciparum from high throughput sequencing data
Bioinformatics 2017 DOI: 10.1093/bioinformatics/btx5307 Jun 2017
Evidence from a natural experiment that malaria parasitemia is pathogenic in retinopathy-negative cerebral malaria
eLife 2017 6 e2369 DOI: 10.7554/eLife.2369925 May 2017
Malaria host candidate genes validated by association with current, recent and historic measures of transmission intensity
The Journal of Infectious Diseases 2017 DOI: 10.1093/infdis/jix25026 Jan 2017
THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites
PLoS Computational Biology 2017 13(1) e1005348 DOI: 10.1371/journal.pcbi.100534825 Jan 2017
Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution
Nature 2017 DOI: 10.1038/nature2103824 Jan 2017
Culture adaptation of malaria parasites selects for convergent loss-of-function mutants
Scientific Reports 2017 7 41303 DOI: 10.1038/srep4130319 Dec 2016
Extreme mutation bias and high AT content in Plasmodium falciparum
Nucleic Acids Research 2016 pii gkw1259 DOI: 10.1093/nar/gkw125914 Oct 2016
Independent origin and global distribution of distinct Plasmodium vivax Duffy Binding Protein gene duplications
PLoS Neglected Tropical Diseases 2016 10(10) e0005091 DOI: 10.1371/journal.pntd.00050918 Mar 2016
The ethics of sustainable genomic research in Africa
Genome Biology 2016 17 44 DOI: 10.1186/s13059-016-0914-316 Jul 2015
Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity
BMC Genomics 2015 16 527 DOI: 10.1186/s12864-015-1746-316 Jun 2015
Understandings of genomic research in developing countries: a qualitative study of the views of MalariaGEN participants in Mali
BMC Medical Ethics 2015 16 42 DOI: 10.1186/s12910-015-0035-715 Apr 2015
K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa
Journal of Infectious Diseases 2015 211(8) 1352-5 DOI: 10.1093/infdis/jiu60824 Mar 2015
USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania
Journal of Infectious Diseases 2015 212(7) 1129-39 DOI: 10.1093/infdis/jiv19223 Feb 2015
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia
Journal of Infectious Diseases 2015 212(4) 626-34 DOI: 10.1093/infdis/jiv09822 Feb 2015
G6PD gene variants and its association with malaria in a Sri Lankan population
Malaria Journal 2015 14 93 DOI: 10.1186/s12936-015-0603-911 Feb 2015
African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania
PloS Genetics 2015 11(2) e1004960 DOI: 10.1371/journal.pgen.100496015 Dec 2014
Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates
Journal of Infectious Diseases 2014 210(12) 1991-2000 DOI: 10.1093/infdis/jiu34913 Aug 2014
Knowing who to trust: exploring the role of 'ethical metadata' in mediating risk of harm in collaborative genomics research in Africa
BMC Medical Ethics 2014 15 62 DOI: 10.1186/1472-6939-15-6211 Jul 2014
Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali
Malaria Journal 2014 13 270 DOI: 10.1186/1475-2875-13-27025 Jun 2014
Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation
Nature Communications 2014 5 4248 DOI: 10.1038/ncomms524816 Jun 2014
Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study
Malaria Journal 2014 13 236 DOI: 10.1186/1475-2875-13-23627 Nov 2013
Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon
PLoS One 2013 8(11) e81071 DOI: 10.1371/journal.pone.00810712 Oct 2013
Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali
PLoS One 2013 8(10) e75675 DOI: 10.1371/journal.pone.007567523 May 2013
Imputation-based meta-analysis of severe malaria in three African populations
PloS Genetics 2013 9(5) e1003509 DOI: 10.1371/journal.pgen.10035091 Nov 2012
Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites
PLoS Genetics 2012 8(11) e1002992 DOI: 10.1371/journal.pgen.100299229 Oct 2012
Candidate human genetic polymorphisms and severe malaria in a Tanzanian population
PLoS One 2012 7(10) e47463 DOI: 10.1371/journal.pone.0047463- 1 of 2
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