Publications

Latest publications

25 Jan 2017

Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

Rutledge GG, Böhme U, Sanders M, Reid AJ, Cotton JA, Maiga-Ascofare O, Djimdé AA, Apinjoh TO, Amenga-Etego L, Manske M, Barnwell JW, Renaud F, Ollomo B, Prugnolle F, Anstey NM, Auburn S, Price RN, McCarthy JS, Kwiatkowski DP, Newbold C, Berriman M, Otto TD
Nature 2017 DOI: 10.1038/nature21038
24 Jan 2017

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants

Claessens A, Affara M, Assefa SA, Kwiatkowski DP, Conway DJ
Scientific Reports 2017 7 41303 DOI: 10.1038/srep41303
9 Jan 2017

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

Clarke GM, Rockett K, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu OK, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Sepúlveda N, Clark TG, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Hoan Phu N, Ngoc Quyen N, Quang Thai C, Tinh Hien T, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TME, Michon P, Mueller I Molloy SF, Campino S, Kerasidou A, Cornelius VJ, Hart L, Shah SS, Band G, Spencer CCA, Agbenyega T, Achidi E, Doumbo OK, Farrar J, Marsh K, Taylor T, Kwiatkowski DP, MalariaGEN Consortium
eLife 2017 6 e15085 DOI: 10.7554/eLife.15085
20 Dec 2016

Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification

Oyola SO, Ariani CV, Hamilton W, Kekre M, Amenga-Etego L, Ghansah A, Rutledge GR, Redmond S, Manske M, Jyothi D, Jacob CG, Otto T, Rockett K, Newbold CI, Berriman M, Kwiatkowski P
Malaria Journal 2016 15 597 DOI: 10.1186/s12936-016-1641-7
20 Dec 2016

Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification

Oyola SO, Ariani CV, Hamilton W, Kekre M, Amenga-Etego L, Ghansah A, Rutledge GR, Redmond S, Manske M, Jyothi D, Jacob CG, Otto T, Rockett K, Newbold CI, Berriman M, Kwiatkowski P
Malaria Journal 2016 15 597 DOI: 10.1186/s12936-016-1641-7
19 Dec 2016

Extreme mutation bias and high AT content in Plasmodium falciparum

Hamilton WL, Claessens A, Otto TD, Kekre M, Fairhurst RM, Rayner JC, Kwiatkowski D
Nucleic Acids Research 2016 pii gkw1259 DOI: 10.1093/nar/gkw1259
3 Nov 2016

Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study

Amato R, Lim P, Miotto O, Amaratunga C, Dek D, Pearson RD, Almagro-Garcia J, Neal AT, Sreng S, Suon S, Drury E, Jyothi D, Stalker J, Kwiatkowski DP, Fairhurst RM
The Lancet Infectious Diseases 2016 DOI: 10.1016/S1473-3099(16)30409-1
14 Oct 2016

Independent origin and global distribution of distinct Plasmodium vivax Duffy Binding Protein gene duplications

Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, Rayner JC
PLoS Neglected Tropical Diseases 2016 10(10) e0005091 DOI: 10.1371/journal.pntd.0005091
16 Aug 2016

Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum

Miles A, Iqbal Z, Vauterin P, Pearson R, Campino S, Theron M, Gould K, Mead D, Drury E, O'Brien J, Ruano Rubio V, MacInnis B, Mwangi J, Samarakoon U, Ranford-Cartwright L, Ferdig M, Hayton K, Su XZ, Wellems T, Rayner J, McVean G, Kwiatkowski D
Genome Research 2016 26 1288-1299 DOI: 10.1101/gr.203711.115.
21 Jun 2016

Admixture into and within sub-Saharan Africa

Busby G, Band G, Le SQ, Jallow M, Bougama E, Mangano V, Amenga-Etego L, Emil A, Apinjoh T, Ndila C, Manjurano A, Nyirongo V, Doumbo O, Rockett K, Kwiatkowski D, Spencer C, The Malaria Genomic Epidemiology Network
eLife 2016 5:e15266 DOI: 10.7554/eLife.15266
8 Mar 2016

The ethics of sustainable genomic research in Africa

Parker M, Kwiatkowski DP
Genome Biology 2016 17 44 DOI: 10.1186/s13059-016-0914-3
4 Mar 2016

Genomic epidemiology of artemisinin resistant malaria

MalariaGEN P. falciparum Community Project
eLife 2016 5 e08714 DOI: 10.7554/eLife.08714
30 Sep 2015

A novel locus of resistance to severe malaria in a region of ancient balancing selection

Malaria Genomic Epidemiology Network
Nature 2015 526(7572) 253-257 DOI: 10.1038/nature15390
28 Aug 2015

Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Shelton JM, Corran P, Risley P, Silva N, Hubbart C, Jeffreys A, Rowlands K, Craik R, Cornelius V, Hensmann M, Molloy S, Sepulveda N, Clark TG, Band G, Clarke GM, Spencer CC, Kerasidou A, Campino S, Auburn S, Tall A, Ly AB, Mercereau-Puijalon O, Sakuntabhai A, Djimdé A, Maiga B, Touré O, Doumbo OK, Dolo A, Troye-Blomberg M, Mangano VD, Verra F, Modiano D, Bougouma E, Sirima SB, Ibrahim M, Hussain A, Eid N, Elzein A, Mohammed H, Elhassan A, Elhassan I, Williams TN, Ndila C, Macharia A, Marsh K, Manjurano A, Reyburn H, Lemnge M, Ishengoma D, Carter R, Karunaweera N, Fernando D, Dewasurendra R, Drakeley CJ, Riley EM, Kwiatkowski DP, Rockett KA; MalariaGEN Consortium
Malaria Journal 2015 14 333 DOI: 10.1186/s12936-015-0833-x
16 Jul 2015

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity

Duffy CW, Assefa SA, Abugri J, Amoako N, Owusu-Agyei S, Anyorigiya T, MacInnis B, Kwiatkowski DP, Conway DJ, Awandare GA
BMC Genomics 2015 16 527 DOI: 10.1186/s12864-015-1746-3
16 Jun 2015

Understandings of genomic research in developing countries: a qualitative study of the views of MalariaGEN participants in Mali

Traore K, Bull S, Niare A, Konate S, Thera MA, Kwiatkowski D, Parker M, Doumbo OK
BMC Medical Ethics 2015 16 42 DOI: 10.1186/s12910-015-0035-7
15 Apr 2015

K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa

Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D, Johnson K, Mumba D, Kekre M, Yavo W, Mead D, Bouyou-Akotet M, Apinjoh T, Golassa L, Randrianarivelojosia M, Andagalu B, Maiga-Ascofare O, Amambua-Ngwa A, Tindana P, Ghansah A, MacInnis B, Kwiatkowski D, Djimde AA
Journal of Infectious Diseases 2015 211(8) 1352-5 DOI: 10.1093/infdis/jiu608
24 Mar 2015

USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania

Manjurano A, Sepúlveda N, Nadjm B, Mtove G, Wangai H, Maxwell C, Olomi R, Reyburn H, Drakeley CJ, Riley EM, Clark TG; in Collaboration With MalariaGEN
Journal of Infectious Diseases 2015 212(7) 1129-39 DOI: 10.1093/infdis/jiv192
23 Feb 2015

Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia

Mangano VD, Kabore Y, Bougouma EC, Verra F, Sepulveda N, Bisseye C, Santolamazza F, Avellino P, Tiono AB, Diarra A, Nebie I, Rockett KA, Sirima SB, Modiano D; MalariaGEN Consortium
Journal of Infectious Diseases 2015 212(4) 626-34 DOI: 10.1093/infdis/jiv098
22 Feb 2015

G6PD gene variants and its association with malaria in a Sri Lankan population

Dewasurendra RL, Rockett KA, Fernando SD, Carter R, Kwiatkowski DP, Karunaweera ND; MalariaGEN Consortium
Malaria Journal 2015 14 93 DOI: 10.1186/s12936-015-0603-9
11 Feb 2015

African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania

Manjurano A, Sepulveda N, Nadjm B, Mtove G, Wangai H, Maxwell C, Olomi R, Reyburn H, Riley EM, Drakeley CJ, Clark TG; MalariaGEN Consortium
PloS Genetics 2015 11(2) e1004960 DOI: 10.1371/journal.pgen.1004960
19 Jan 2015

Genetic architecture of artemisinin-resistant Plasmodium falciparum

Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J, Amaratunga C, Lim P, Mead D, Oyola SO, Dhorda M, Imwong M, Woodrow C, Manske M, Stalker J, Drury E, Campino S, Amenga-Etego L, Thanh TN, Tran HT, Ringwald P, Bethell D, Nosten F, Phyo AP, Pukrittayakamee S, Chotivanich K, Chuor CM, Nguon C, Suon S, Sreng S, Newton PN, Mayxay M, Khanthavong M, Hongvanthong B, Htut Y, Han KT, Kyaw MP, Faiz MA, Fanello C, Onyamboko M, Mokuolu OA, Jacob CG, Takala-Harrison S, Plowe CV, Day NP, Dondorp AM, Spencer CC, McVean G, Fairhurst RM, White NJ, Kwiatkowski DP
Nature Genetics 2015 47(3) 226-34 DOI: 10.1038/ng.3189
15 Dec 2014

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates

Ocholla H, Preston MD, Mipando M, Jensen AT, Campino S, MacInnis B, Alcock D, Terlouw A, Zongo I, Oudraogo JB, Djimde AA, Assefa S, Doumbo OK, Borrmann S, Nzila A, Marsh K, Fairhurst RM, Nosten F, Anderson TJ, Kwiatkowski DP, Craig A, Clark TG, Montgomery J
Journal of Infectious Diseases 2014 210(12) 1991-2000 DOI: 10.1093/infdis/jiu349
28 Sep 2014

Reappraisal of known malaria resistance loci in a large multi-centre study

Rockett KA, Clarke GM, Fitzpatrick K, Hubbart C, Jeffreys AE, Rowlands K, Craik R, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu O, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NT, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Green A, Molloy S, Johnson KJ, Kerasidou A, Cornelius V, Hart L, Vanderwal A, SanJoaquin M, Band G, Le SQ, Pirinen M, Sepúlveda N, Spencer CC, Clark TG, Agbenyega T, Achidi E, Doumbo O, Farrar J, Marsh K, Taylor T, Kwiatkowski DP for Malaria Genomic Epidemiology Network
Nature Genetics 2014 46(11) 1197-204 DOI: 10.1038/ng.3107
13 Aug 2014

Knowing who to trust: exploring the role of 'ethical metadata' in mediating risk of harm in collaborative genomics research in Africa

de Vries J, Williams TN, Bojang K, Kwiatkowski DP, Fitzpatrick R, Parker M
BMC Medical Ethics 2014 15 62 DOI: 10.1186/1472-6939-15-62
11 Jul 2014

Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali

Maiga B, Dolo A, Campino S, Sepulveda N, Corran P, Rockett KA, Troye-Blomberg M, Doumbo OK, Clark TG
Malaria Journal 2014 13 270 DOI: 10.1186/1475-2875-13-270
25 Jun 2014

Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation

Clarkson CS, Weetman D, Essandoh J, Yawson AE, Maslen G, Manske M, Field SG, Webster M, Antão T, MacInnis B, Kwiatkowski D, Donnelly MJ
Nature Communications 2014 5 4248 DOI: 10.1038/ncomms5248
16 Jun 2014

Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study

Apinjoh TO, Anchang-Kimbi JK, Njua-Yafi C, Ngwai AN, Mugri RN, Clark TG, Rockett KA, Kwiatkowski DP, Achidi EA; MalariaGEN Consortium
Malaria Journal 2014 13 236 DOI: 10.1186/1475-2875-13-236
27 Nov 2013

Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon

Apinjoh TO, Anchang-Kimbi JK, Njua-Yafi C, Mugri RN, Ngwai AN, Rockett KA, Mbunwe E, Besingi RN, Clark TG, Kwiatkowski DP, Achidi EA; MalariaGEN Consortium
PLoS One 2013 8(11) e81071 DOI: 10.1371/journal.pone.0081071
2 Oct 2013

Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali

Maiga B, Dolo A, Touré O, Dara V, Tapily A, Campino S, Sepulveda N, Risley P, Silva N, Corran P, Rockett KA, Kwiatkowski D; MalariaGEN Consortium, Clark TG, Troye-Blomberg M, Doumbo OK
PLoS One 2013 8(10) e75675 DOI: 10.1371/journal.pone.0075675