1008 Containment of artemisinin tolerant malaria parasites in Southeast Asia (ARCE)


Locations: Laos (LA), Myanmar (MM), Vietnam (VN)

Partner study description

ARCE is a WHO-lead strategy for the containment of artemisinin resistant parasites in Southeast Asia, aiming to ultimately contribute to the elimination of falciparum malaria from the area. Samples collected as part of ARCE-lead studies of artesunate efficacy at sites in Myanmar, Laos and Viet Nam were contributed to the MalariaGEN P. falciparum Community Project for whole genome sequencing and subsequent analysis of genetic variation, population structure and signatures of selection. The genetic data is also being used in a replication genome-wide association study to validate and extend the outcomes of the ARC3 GWAS, with the hope of identifying molecular markers of artemisinin resistance.

Key People

Assoc Prof Mayfong Mayxay
Head of Field Research
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Vientiane, Lao PDR
Institute of Research and Education Development (IRED), University of Health Sciences, Ministry of Health, Vientiane, Lao PDR
Dr Myat Phone Kyaw
The Myanmar Oxford Clinical Research Unit, University of Oxford, Myanmar
University of Public Health, Yangon, Myanmar
Dr Shannon Takala-Harrison
Center for Vaccine Development and Global Health, University of Maryland, School of Medicine, Baltimore, MD, USA