1125 Investigating artemisinin resistance emergence on Thai-Burmese border


Locations: Thailand (TH)

Partner study description

Plasmodium falciparum resistance to artemisinin derivatives emerged on the Thai Myanmar border between 2000 and 2010. The Shoklo Malaria Research Unit (SMRU) has collected phenotypic data on more than 3,000 patients with uncomplicated hyperparasitaemia and stored packed red blood cells for over 600 at the time of admission. This constitutes a unique collection of samples available for genomic analysis to determine changes in the parasite population structures and to identify potential molecular markers associated with resistance to artesunate.

Key People

Prof Francois Nosten
Professor in Tropical Medicine, Group Head / PI, Consultant Physician and Fellow
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine Research building, University of Oxford Old Road campus, Oxford, UK
Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand