1127 Genetic analysis of P. falciparum before and after artemether-lumefantrine treatment in Mali

Projects:

Locations: Mali (ML)

Partner study description

Although artemisinin combination therapy (ACT) resistance has not yet been found in Mali, previous studies have shown that cases of recurring P. falciparum parasites within a month of infection after treatment with artemether-lumefantrine seem to be increasing. The Molecular Epidemiology and Drug Resistance Unit, at the Malaria Research and Training Center, University of Science, Techniques and Technologies of Bamako, Mali is conducting this study to characterise the phenotype and genotype of these recurrent parasites, with parasites being collected before and after artemether-lumefantrine treatment and stored for ex vivo drug efficacy studies and subsequent genotyping by next generation sequencing.

Key People

Prof Abdoulaye Djimdé
Associate Professor of Parasitology and Mycology; Chief of the Molecular Epidemiology and Drug Resistance Unit
Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Mali
Wellcome Trust International Fellow
Malaria Programme, Wellcome Trust Sanger Institute, UK
Souleymane Dama
Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Mali