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1010 Genetic variation underlying drug resistance at the Thai-Burmese border

Location: Thailand (TH).


Partner study description

In one of the first partnerships of the MalariaGEN P. falciparum Community Project, Timothy Anderson and colleagues used whole genome sequencing and genotyping to identify genetic variants that underpin drug resistance in Plasmodium falciparum. Working with Francois Nosten at his field site in Mae Sot on the Thai-Burmese border, clinical parasite samples were collected, cloned and lab-adapted to use for both genetic and phenotypic analyses, namely evaluating drug resistance in vitro. The central aim of the project was to combine these analyses to investigate genotype-phenotype association using high-resolution SNP data generated by Illumina sequencing, as well as traditional genotyping platforms.