Partner study description
In one of the first partnerships of the MalariaGEN P. falciparum Community Project, Timothy Anderson and colleagues used whole genome sequencing and genotyping to identify genetic variants that underpin drug resistance in Plasmodium falciparum. Working with Francois Nosten at his field site in Mae Sot on the Thai-Burmese border, clinical parasite samples were collected, cloned and lab-adapted to use for both genetic and phenotypic analyses, namely evaluating drug resistance in vitro. The central aim of the project was to combine these analyses to investigate genotype-phenotype association using high-resolution SNP data generated by Illumina sequencing, as well as traditional genotyping platforms.
Genomic epidemiology of artemisinin resistant malaria
MalariaGEN P. falciparum Community ProjecteLife, 2016; 5 e08714
Genetic architecture of artemisinin-resistant Plasmodium falciparum
Miotto et alNature Genetics, 2015; 47(3) 226-34
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Miotto et alNature Genetics, 2013; 45(6) 648-55