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1127 Genetic analysis of Plasmodium falciparum before and after artemether-lumefantrine treatment in Mali

Location: Mali (ML).


Partner study description

Although artemisinin combination therapy (ACT) resistance has not yet been found in Mali, previous studies have shown that cases of recurring Plasmodium falciparum parasites within a month of infection after treatment with artemether-lumefantrine seem to be increasing. The Molecular Epidemiology and Drug Resistance Unit, at the Malaria Research and Training Center, University of Science, Techniques and Technologies of Bamako, Mali is conducting this study to characterise the phenotype and genotype of these recurrent parasites, with parasites being collected before and after artemether-lumefantrine treatment and stored for ex vivo drug efficacy studies and subsequent genotyping by next generation sequencing.