Evolutionary history and genetic adaptation of  Plasmodium vivax (1258-PV-MULTI-ROUGERON-SM)

This study proposes to generate a global understanding of how pathogens adapt to new environments, using Plasmodium vivax as model system, by using technology in the field of genomics, population genetics, informatics and evolution. 

The first AIM of this proposal is to study the “intertwined” host-pathogen evolutionary histories of humans and great apes and of P. vivax  and P. vivax-like. The second AIM is to characterize the mechanisms involved in the adaptation of P. vivax and P. vivax-like to their respective hosts and of different P. vivax populations.

Sample locations: Afghanistan, Armenia, Azerbaijan, Bangladesh, Cameroon, Comoros, India, Mauritania, Senegal and Turkey.

Publications

• Genomic exploration of the journey of Plasmodium vivax in Latin America
  Lefebvre et al
  PLoS Pathogens, 2025;
  10.1371/journal.ppat.1012811